MONKEY MODELS AND WOMEN'S HEALTH

猴子模型与女性健康

• 批准号: 3100461
• 负责人: THOMAS B CLARKSON
• 金额: $ 31.1万
• 依托单位: WAKE FOREST UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-06-01 至 1996-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3100461
• 关键词: Primates; female; health care; health care model; model design /development

This is a multi-categorical Program Project that takes advantage of many years of developing a female cynomolgus monkey model to better understand women's health, introduces some innovative approaches to nonhuman primate research, and strengthens the environment for research and research training. The research will be conducted at the Comparative Medicine Clinical Research Center (CMCRC), a unique resource of the Bowman Gray School of Medicine of Wake Forest University. The Program Project contains three separate experiments that encompass important new directions in comparative medicine research: * An investigation of naturally occurring osteoarthritis to better understand that disorder in women * A study of the effects of estrogen replacement therapy on regional adiposity and the relationships between intra-abdominal fat and risk factors for diabetes mellitus, cardiovascular disease, and coronary artery atherosclerosis * A collaboration with researchers in Indonesia to investigate the effects of vitamin E supplementation versus estrogen replacement therapy on development of coronary artery atherosclerosis. Part of this study will be conducted in Indonesia and part at the CMCRC. In addition, the Program Project contains four cores that are devoted respectively to administration, comparative pathology, laboratory animal medicine, and biostatistics and data services. These cores comprise the infrastructure that enables the research projects to occur.

这是一个多类别的计划项目，利用了许多 多年来开发雌性食蟹猴模型， 妇女健康，介绍了一些创新的方法， 研究，并加强研究和研究的环境 训练这项研究将在比较医学中心进行。 临床研究中心（CMCRC），鲍曼格雷的独特资源 维克森林大学医学院。方案项目 包含三个独立的实验， 比较医学研究方向： * 自然发生的骨关节炎的研究，以更好地 了解到女性的失调 * 雌激素替代治疗对局部脑缺血的影响 肥胖和腹内脂肪与风险之间的关系 糖尿病、心血管疾病和冠状动脉疾病 动脉粥样硬化 * 与印度尼西亚的研究人员合作， 补充维生素E与雌激素替代疗法的效果 冠状动脉粥样硬化的发展。本研究的一部分 将在印度尼西亚进行，部分在CMCRC进行。 此外，该计划项目包含四个核心， 分别用于给药、比较病理学、实验动物 医学、生物统计和数据服务。这些核心包括 基础设施，使研究项目能够发生。