COVID-19: Longitudinal immunological and multi-omic profiling of haemodialysis patients

COVID-19：血液透析患者的纵向免疫学和多组学分析

• 批准号: MR/V027638/1
• 负责人: James Peters
• 金额: $ 75.03万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FV027638%2F1
• 关键词: COVID; 19; Longitudinal; immunological; multi

COVID-19, caused by infection with SARS-CoV-2 ('coronavirus'), is a global emergency. Although most people suffer only mild symptoms, some people get seriously ill and the disease is deadly in around 1%. Patients with kidney disease are at high risk of developing serious illness. We urgently need new treatments for COVID-19. In order to develop them, we need to understand why some people get so ill. In these people, we think that the virus causes the body's immune system to goes into 'overdrive' and this causes collateral damage to the body. It is likely that this damage is caused by cells, genes and proteins involved in the immune response to the virus. To understand which ones are causing the problem, we have taken blood samples from patients with kidney disease who are receiving dialysis treatment 3 times a week and who have been infected with COVID-19. This means that we can look at blood samples over time to understand which genes are being switched on and which proteins are changing, particularly in patients who develop the most severe form of the disease. This will help us decide which drugs might help patients and improve survival.

COVID-19由SARS-CoV-2（冠状病毒）感染引起，是一种全球性紧急情况。虽然大多数人只有轻微的症状，但有些人会得重病，大约1%的人会致命。肾病患者患严重疾病的风险很高。我们迫切需要新的COVID-19治疗方法。为了开发它们，我们需要了解为什么有些人会生病。在这些人中，我们认为病毒导致身体的免疫系统进入“免疫”状态，这对身体造成了附带损害。这种损害很可能是由参与对病毒的免疫反应的细胞、基因和蛋白质引起的。为了了解是哪些因素导致了这一问题，我们从每周接受3次透析治疗并感染了COVID-19的肾病患者身上采集了血液样本。这意味着我们可以通过观察血液样本来了解哪些基因正在被打开，哪些蛋白质正在发生变化，特别是在发展为最严重疾病的患者中。这将帮助我们决定哪些药物可能帮助患者并提高生存率。

项目成果

Plasma Lectin Pathway Complement Proteins in Patients With COVID-19 and Renal Disease.

• DOI: 10.3389/fimmu.2021.671052
• 发表时间: 2021
• 期刊: Frontiers in immunology
• 影响因子: 7.3
• 作者: Medjeral-Thomas NR;Troldborg A;Hansen AG;Gisby J;Clarke CL;Prendecki M;McAdoo SP;Sandhu E;Lightstone L;Thomas DC;Willicombe M;Botto M;Peters JE;Pickering MC;Thiel S
• 通讯作者: Thiel S

Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death

COVID-19 透析患者的纵向蛋白质组学分析揭示了严重程度标志物和死亡预测因素

• DOI: 10.1101/2020.11.05.20223289
• 发表时间: 2020
• 作者: Gisby J

Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death.

• DOI: 10.7554/elife.64827
• 发表时间: 2021-03-11
• 期刊: eLife
• 影响因子: 7.7
• 作者: Gisby J;Clarke CL;Medjeral-Thomas N;Malik TH;Papadaki A;Mortimer PM;Buang NB;Lewis S;Pereira M;Toulza F;Fagnano E;Mawhin MA;Dutton EE;Tapeng L;Richard AC;Kirk PD;Behmoaras J;Sandhu E;McAdoo SP;Prendecki MF;Pickering MC;Botto M;Willicombe M;Thomas DC;Peters JE
• 通讯作者: Peters JE

Multi-omics identify falling LRRC15 as a COVID-19 severity marker and persistent pro-thrombotic signals in convalescence.

• DOI: 10.1038/s41467-022-35454-4
• 发表时间: 2022-12-15
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Gisby, Jack S.;Buang, Norzawani B.;Papadaki, Artemis;Clarke, Candice L.;Malik, Talat H.;Medjeral-Thomas, Nicholas;Pinheiro, Damiola;Mortimer, Paige M.;Lewis, Shanice;Sandhu, Eleanor;McAdoo, Stephen P.;Prendecki, Maria F.;Willicombe, Michelle;Pickering, Matthew C.;Botto, Marina;Thomas, David C.;Peters, James E.
• 通讯作者: Peters, James E.

Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVID-19 respiratory disease.

• DOI: 10.1016/j.immuni.2022.01.017
• 发表时间: 2022-03-08
• 期刊: Immunity
• 影响因子: 32.4
• 作者: Vijayakumar B;Boustani K;Ogger PP;Papadaki A;Tonkin J;Orton CM;Ghai P;Suveizdyte K;Hewitt RJ;Desai SR;Devaraj A;Snelgrove RJ;Molyneaux PL;Garner JL;Peters JE;Shah PL;Lloyd CM;Harker JA
• 通讯作者: Harker JA