INFANT NUTRITIONAL FORMULA FOR EFFICACY AGAINST RSV INFECTION IN RHESUS MONKEYS

有效对抗恒河猴 RSV 感染的婴儿营养配方奶粉

• 批准号: 6277411
• 负责人: VICKI L TRAINA-DORGE
• 金额: $ 8.78万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6277411
• 关键词: Mammalia; Primates; animal tissue; drug /agent; infection; nutrition; nutrition related tag; respiratory system; virus

Respiratory syncytial virus (RSV) infection is a major cause of serious life-threatening lower respiratory tract disease in infants and young children under the age of three. Hospitalized children with underlying heart and lung conditions are at the most risk for severe complications and death due to infection with this agent. No effective vaccine is available, and the current antiviral drug available, has limited use. We conducted an animal study in collaboration with Ross Laboratories. They again provided us with potential antiviral compounds in a nutritional infant formula to test for their therapeutic efficiacy. Sixteen one year old rhesus monkeys were taken off of solid foods, divided into two groups, and given either of the two Abbott formulas. The animals were then given an intranasal RSV challenge and then followed for three weeks to monitor viral shedding in both the upper and lower respiratory tract to determine the efficiacy of the test formula. Infections in the upper respiratory tract of both groups appeared to be similar. Histologically, one group of animals showed more inflammation in lung histopathology that the other formula fed group. In conclusion, the nutritional formulas tested in this study were minimally effective against RSV in the lower respiratory tract of treated

呼吸道合胞病毒（RSV）感染是导致呼吸道感染的主要原因。 婴儿严重危及生命的下呼吸道疾病 以及三岁以下的儿童。 住院患儿 潜在的心脏和肺部疾病是最危险的严重 并发症和死亡，由于感染这种代理。 没有 有效的疫苗是可用的，目前的抗病毒药物 可用，用途有限。 我们进行了一项动物研究， 与罗斯实验室合作。 他们再次为我们提供了 测试婴儿营养配方中潜在的抗病毒化合物 因为他们的治疗效果。 十六只一岁的恒河猴 不吃固体食物，分成两组， 两种雅培配方中的任何一种 然后给这些动物一个 鼻内RSV激发，然后随访三周以监测 上呼吸道和下呼吸道的病毒脱落， 确定测试公式的有效性。 上腹部感染 两组的呼吸道表现相似。 在组织学上，一组动物的肺部炎症更多 组织病理学检查结果与其他配方奶粉喂养组相同。 最后 这项研究中测试的营养配方是最低限度有效的， 治疗组下呼吸道中的RSV