INFANT NUTRITIONAL FORMULA FOR EFFICACY AGAINST RSV INFECTION IN RHESUS MONKEYS

呼吸道合胞病毒(RSV)感染是导致 婴幼儿严重威胁生命的下呼吸道疾病 以及三岁以下的儿童。住院的儿童患有 潜在的心肺疾病最有可能导致严重的 因感染该制剂而引起的并发症和死亡。不是 有效的疫苗已经问世，目前的抗病毒药物 可用，但用途有限。我们在中国进行了一项动物研究 与罗斯实验室的合作。他们再次为我们提供了 一种营养婴儿配方奶粉中潜在的抗病毒化合物将进行测试 因为他们的治疗效果。16只1岁的恒河猴 从固体食物中脱掉，分成两组，并给予 两个雅培公式中的任何一个。然后这些动物被给予了一种 鼻腔内RSV激发，然后跟踪监测三周 病毒在上呼吸道和下呼吸道中脱落 确定测试配方的效率。上半身感染 两组患者的呼吸道似乎相似。 组织学上，一组动物表现出更多的肺部炎症。 另一配方饲料组为组织病理学检查。总而言之， 在这项研究中测试的营养配方是最小有效的 抗呼吸道合胞病毒治疗后下呼吸道感染

Respiratory syncytial virus (RSV) infection is a major cause of serious life-threatening lower respiratory tract disease in infants and young children under the age of three. Hospitalized children with underlying heart and lung conditions are at the most risk for severe complications and death due to infection with this agent. No effective vaccine is available, and the current antiviral drug available, has limited use. We conducted an animal study in collaboration with Ross Laboratories. They again provided us with potential antiviral compounds in a nutritional infant formula to test for their therapeutic efficiacy. Sixteen one year old rhesus monkeys were taken off of solid foods, divided into two groups, and given either of the two Abbott formulas. The animals were then given an intranasal RSV challenge and then followed for three weeks to monitor viral shedding in both the upper and lower respiratory tract to determine the efficiacy of the test formula. Infections in the upper respiratory tract of both groups appeared to be similar. Histologically, one group of animals showed more inflammation in lung histopathology that the other formula fed group. In conclusion, the nutritional formulas tested in this study were minimally effective against RSV in the lower respiratory tract of treated