AGING RELATED REACTIVATION OF X CHROMOSOME GENES

与衰老相关的 X 染色体基因重新激活

• 批准号: 6113373
• 负责人: David T. BURKE
• 金额: $ 0.02万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6113373
• 关键词: aging; animal genetic material tag; developmental genetics; female; gene expression; gene induction /repression; laboratory mouse; sex chromosomes

The non-specific loss of correct gene regulation is thought to play a major role in both aging and cancer. A specific example of aging-dependent genetic change is the reactivation of genes from normally inactive female X-chromosomes. The project is examining reactivated expression from genes across the entire mouse X chromosome, as well as from a defined segment of the X where reactivation has previously been shown to occur.

正确基因调控的非特异性丧失被认为在衰老和癌症中起主要作用。 衰老相关的遗传变化的一个具体例子是来自通常不活跃的女性X染色体的基因的重新激活。 该项目正在检查整个小鼠X染色体基因的重新激活表达，以及X染色体的一个定义片段，其中重新激活先前已被证明会发生。