GROWTH RETARDATION--HPA AXIS RESPONSE TO CRH AND CORTISOL CHALLENGES

生长迟缓——HPA 轴对 CRH 和皮质醇挑战的反应

• 批准号: 6297120
• 负责人: Delia M Vazquez
• 金额: $ 0.02万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6297120
• 关键词: child (0-11); clinical research; corticotropin releasing factor; cortisol; hormone regulation /control mechanism; human subject; hypothalamic pituitary adrenal axis; pituitary dwarfism; postnatal growth disorder; psychological stressor; somatotropin; stress

This proposal studies the growth hormone (GH) and hypothalamic pituitary adrenal (HPA) axis physiology in children with short stature and psychosocial dwarfs. The aim is to address the possibility that: repeated psychological stress during development activates the HPA axis; leads to an abnormal regulation of its elements and this ultimately is conducive to a tonic inhibition on GH release and growth failure.

本研究旨在探讨矮小及社会心理性侏儒儿童的生长激素（GH）及下丘脑-垂体-肾上腺（HPA）轴的生理变化。 其目的是解决的可能性，即：在发展过程中反复的心理压力激活HPA轴;导致其元素的异常调节，这最终有利于对GH释放和生长失败的滋补抑制。