MOLECULAR BIOLOGY OF GASTRIC MUCOSAL CELLS

胃粘膜细胞的分子生物学

• 批准号: 6113377
• 负责人: Tadataka Yamada
• 金额: $ 2.14万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6113377
• 关键词: carbonate dehydratase; computer assisted sequence analysis; gastric mucosa; gastrins; gene expression; hormone receptor; molecular cloning; peptide hormone; protein structure function; sodium potassium exchanging ATPase; somatostatin

This study is directed at examining the biosynthesis post-translational processing and biological activity of peptide hormones in the gut as they interact to regulate gastric acid secretion. The focus of this protocol will be to explore the molecular biology of the enzymes carbonic anhydrase and H{+}K{+}-ATPase, as well as the hormones gastrin and somatostatin. We propose to utilize the GCRC computer to assist us with gene sequence analysis for comparison with other biological substances.

本研究旨在考察翻译后的生物合成。 多肽激素在肠道AS中的加工和生物活性 它们相互作用，调节胃酸的分泌。这件事的重点是 协议将探索酶的分子生物学 碳酸氢酶和H+K+-ATPase，以及激素胃泌素 和生长抑素。我们建议利用GCRC计算机来帮助我们 用基因序列分析与其他生物进行比较 物质。