BIOLOGICAL EFFECTS OF DHEA AND/OR EXERCISE IN ELDERLY

这将是一项随机、安慰剂对照、双盲(DHEA但不运动)的研究，研究DHEA和运动训练的独立和联合影响。研究对象为96名男性和96名女性，年龄在60-75岁之间，他们身体健康，但久坐不动。他们将被随机接受脱氢表雄酮50 mg/d或安慰剂，并参加监督或家庭运动训练计划。家庭锻炼计划代表了针对本研究中调查的变量的安慰剂锻炼计划，即心输出量和最大摄氧量、肌肉质量和力量、脂肪质量和骨矿物质密度。受监督的锻炼计划将包括阻力和耐力训练部分，旨在增加肌肉质量、力量和骨量，改善心血管功能，减少脂肪量。这项研究的目的是提供有关脱氢表雄酮替代疗法在维持老年人健康和功能能力方面的潜力的信息。

This will be a randomized, placebo-controlled, double-blind (for DHEA but no exercise) study of the independent and combined effects of DHEA and exercise training. Subjects will be 96 men and 96 women, aged 60-75 yr, who are healthy but sedentary. They will be randomized to receive either DHEA 50 mg/d or placebo and to participate in either supervised or home exercise training programs. The home exercise program represents a placebo exercise program with respect to the variables under investigation in this study, i.e., cardiac output and VO max, nusce mass and strength, fat mass, and bone mineral denisity. The supervised exercise program will include both resistance and enduance training components , designed to bring about increases in muscle mass, strength, and bone mass, improvement in cardiovascular function, and a decrease in fat mass. The goal of this research is to provide information regarding the potential of DHEA replacement therapy in maintaining health and functional capacity of the elderly.