Bone Density in Aging Men of Diverse Race and Ethnicity

不同种族和民族的老年男性的骨密度

• 批准号: 6725409
• 负责人: John B McKinlay
• 金额: $ 56.54万
• 依托单位: NEW ENGLAND RESEARCH INSTITUTES, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-15 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6725409
• 关键词: African American; Hispanic Americans; aging; body composition; bone density; bone development; calcium metabolism; caucasian American; clinical research; densitometry; epidemiology; health surveys; human middle age (35-64); human old age (65+); lifestyle; male; osteoporosis; pathologic bone resorption; quality of life; racial /ethnic difference

DESCRIPTION (provided by applicant): The National Institutes of Health (NIH) has identified the prospective investigation of osteoporosis in gender, age, and racially/ethnically diverse populations as an urgent research priority (Consensus Development Conference on Osteoporosis Prevention, Diagnosis, and Therapy. 2000). Male osteoporosis is a highly prevalent medical condition, with enormous impact on the health, medical-care expenditures, and quality of life of the aging U.S. male population. Race/ethnic-specific estimates of the prevalence of osteoporosis from population based. cross-sectional data are limited by: (1) Incomplete information on the range of variables that may be related to both bone density and race/ethnicity (e.g., bone turnover, hormone levels, lifestyle, nutrition, vitamin D status, and others) that might account for the racial/ethnic difference in prevalence; and (2) Limited data on Hispanics other than Mexican Americans, despite the well-known heterogeneity of ethnicities within Hispanic populations. The New England Research Institutes (NERI) has received an award from NIDDK to begin a large epidemiological research study of 3,000 randomly selected, community dwelling Hispanic, non-Hispanic African American, and non-Hispanic Caucasian men ages 40-79 years (1,000 per racial/ethnic group), to provide normative data on four urologic conditions. The proposed study will take advantage of this newly assembled cohort by adding a cross-sectional, population-based sub-study of bone density and osteoporosis in men. We will recruit 900 men from the parent study and describe the distribution of bone mineral density (BMD) and low BMD by race/ethnicity and determine to what extent variables (e.g., health status, lifestyle, sociodemographics, biochemical measures of bone turnover and hormone levels, fracture history) correlate with BMD, and whether the effect of these variables on BMD varies with race/ethnicity. To prepare for the possibility of a future, separately funded prospective study, we will initiate panel maintenance activities with the cohort. This design represents a cost-efficient approach to gathering detailed information focused on bone health in a randomly selected, population-based sample, while taking advantage of the activities currently underway as part of the parent study.

描述（由申请人提供）：美国国立卫生研究院 (NIH) 确定了骨质疏松症在性别、年龄、 和种族/民族多样化人群作为紧急研究重点 （骨质疏松症预防、诊断和治疗共识发展会议 治疗。 2000）。男性骨质疏松症是一种非常普遍的疾病， 对健康、医疗支出和生活质量产生巨大影响 美国男性人口老龄化。种族/族裔特定的估计 骨质疏松症的患病率以人群为主。横截面数据是 受限于： (1) 关于可能的变量范围的信息不完整 与骨密度和种族/民族有关（例如骨转换、激素 水平、生活方式、营养、维生素 D 状况等）可能会影响 种族/族裔患病率差异； (2) 有限的数据 除墨西哥裔美国人外的西班牙裔美国人，尽管众所周知的异质性 西班牙裔人口中的种族。 新英格兰研究所 (NERI) 荣获 NIDDK 颁发的奖项 开始一项随机抽取 3,000 人的大型流行病学研究， 社区住宅西班牙裔、非西班牙裔非裔美国人和非西班牙裔 年龄 40-79 岁的白人男性（每个种族/族裔群体 1,000 名），提供 四种泌尿系统疾病的规范数据。拟议的研究将采取 通过添加横截面，利用这个新组建的队列的优势， 基于人群的男性骨密度和骨质疏松症子研究。我们将 从母体研究中招募 900 名男性并描述骨骼的分布 按种族/民族划分的矿物质密度 (BMD) 和低 BMD，并确定什么 程度变量（例如，健康状况、生活方式、社会人口统计数据、 骨转换和激素水平的生化测量、骨折史） 与 BMD 相关，以及这些变量对 BMD 的影响是否不同 与种族/民族。分别为未来的可能性做准备 资助的前瞻性研究，我们将启动面板维护活动 队列。这种设计代表了一种经济有效的收集方法 随机选择的重点关注骨骼健康的详细信息， 基于人口的样本，同时利用当前的活动 作为家长研究的一部分正在进行。