Bone Density in Aging Men of Diverse Race and Ethnicity

描述(由申请人提供)：美国国立卫生研究院(NIH) 已经确定了关于骨质疏松症的性别、年龄、 和种族/民族多样化的人口作为紧迫的研究优先事项 (骨质疏松症预防、诊断和治疗共识发展会议 心理治疗。2000)。男性骨质疏松症是一种非常普遍的医学疾病， 对健康、医疗保健支出和生活质量的巨大影响 在老龄化的美国男性人口中。种族/民族方面的估计 以人群为基础的骨质疏松症患病率。横截面数据为 受限于：(1)关于可能存在的变量范围的不完整信息 与骨密度和种族/民族有关(例如，骨转换、激素 水平、生活方式、营养、维生素D状态等)，这可能会解释 关于患病率的种族/族裔差异；和(2)关于 除了墨西哥裔美国人之外的拉美裔美国人，尽管众所周知 西班牙裔人口中的种族。 新英格兰研究院(NERI)获得了NIDDK颁发的奖项 开始对随机选择的3000人进行大规模的流行病学研究， 社区居住的西班牙裔、非西班牙裔非裔美国人和非西班牙裔 40-79岁的高加索男子(每个种族/民族1,000人)，提供 四种泌尿科疾病的标准数据。拟议的研究将需要 通过增加一个横截面， 基于人群的男性骨密度和骨质疏松症的分研究。我们会 从父母那里招募900名男性进行研究，并描述骨骼的分布 按种族/民族划分的矿物质密度(BMD)和低BMD及其决定因素 程度变量(例如，健康状况、生活方式、社会人口统计、 骨转换和激素水平、骨折病史的生化指标) 与BMD相关，以及这些变量对BMD的影响是否不同 与种族/民族有关。为未来的可能性做准备，分别 受资助的前瞻性研究，我们将启动面板维修活动 这群人。此设计代表了一种经济高效的收集 详细的信息集中在一个随机选择的骨骼健康， 以人口为基础的样本，同时利用目前的活动 作为家长研究的一部分正在进行中。

DESCRIPTION (provided by applicant): The National Institutes of Health (NIH) has identified the prospective investigation of osteoporosis in gender, age, and racially/ethnically diverse populations as an urgent research priority (Consensus Development Conference on Osteoporosis Prevention, Diagnosis, and Therapy. 2000). Male osteoporosis is a highly prevalent medical condition, with enormous impact on the health, medical-care expenditures, and quality of life of the aging U.S. male population. Race/ethnic-specific estimates of the prevalence of osteoporosis from population based. cross-sectional data are limited by: (1) Incomplete information on the range of variables that may be related to both bone density and race/ethnicity (e.g., bone turnover, hormone levels, lifestyle, nutrition, vitamin D status, and others) that might account for the racial/ethnic difference in prevalence; and (2) Limited data on Hispanics other than Mexican Americans, despite the well-known heterogeneity of ethnicities within Hispanic populations. The New England Research Institutes (NERI) has received an award from NIDDK to begin a large epidemiological research study of 3,000 randomly selected, community dwelling Hispanic, non-Hispanic African American, and non-Hispanic Caucasian men ages 40-79 years (1,000 per racial/ethnic group), to provide normative data on four urologic conditions. The proposed study will take advantage of this newly assembled cohort by adding a cross-sectional, population-based sub-study of bone density and osteoporosis in men. We will recruit 900 men from the parent study and describe the distribution of bone mineral density (BMD) and low BMD by race/ethnicity and determine to what extent variables (e.g., health status, lifestyle, sociodemographics, biochemical measures of bone turnover and hormone levels, fracture history) correlate with BMD, and whether the effect of these variables on BMD varies with race/ethnicity. To prepare for the possibility of a future, separately funded prospective study, we will initiate panel maintenance activities with the cohort. This design represents a cost-efficient approach to gathering detailed information focused on bone health in a randomly selected, population-based sample, while taking advantage of the activities currently underway as part of the parent study.