Bone Density in Aging Men of Diverse Race and Ethnicity

描述（由申请人提供）：美国国立卫生研究院（NIH） 确定了骨质疏松症在性别、年龄 和种族/民族多样化的人口作为一个紧迫的研究优先事项 （骨质疏松症预防、诊断和治疗共识发展会议） 疗法2000年）。男性骨质疏松症是一种非常普遍的医学病症， 对健康、医疗保健支出和生活质量的巨大影响 美国老龄化男性人口的一半。按种族/族裔分列的 骨质疏松症的患病率从人口为基础。横截面数据是 限制因素：（1）关于可能影响评估结果的变量范围的信息不完整。 与骨密度和种族/民族（例如，骨转换，激素 水平、生活方式、营养、维生素D状况和其他）， 流行率的种族/民族差异;和（2）关于以下方面的数据有限 除了墨西哥裔美国人以外的西班牙裔美国人，尽管众所周知的异质性， 西班牙裔人口中的种族。 新英格兰研究所（NERI）获得了NIDDK的奖项， 开始一项大规模的流行病学研究，随机选择3,000人， 社区居住的西班牙裔，非西班牙裔非洲裔美国人和非西班牙裔 40-79岁的白人男性（每个种族/族裔群体1，000人），提供 四种泌尿系统疾病的标准数据。拟议的研究将采取 通过增加一个横截面， 男性骨密度和骨质疏松症的基于人群的子研究。我们将 从母研究中招募900名男性， 矿物质密度（BMD）和低BMD的种族/民族，并确定什么 范围变量（例如，健康状况、生活方式、社会人口统计数据， 骨转换和激素水平的生化指标，骨折史） 与BMD相关，以及这些变量对BMD的影响是否不同 种族/民族。为未来的可能性做准备， 资助的前瞻性研究，我们将启动面板维护活动， 的cohort。这种设计代表了一种具有成本效益的方法， 详细的信息集中在骨骼健康在一个随机选择， 人口抽样，同时利用目前的活动 正在进行中，作为母公司研究的一部分。

DESCRIPTION (provided by applicant): The National Institutes of Health (NIH) has identified the prospective investigation of osteoporosis in gender, age, and racially/ethnically diverse populations as an urgent research priority (Consensus Development Conference on Osteoporosis Prevention, Diagnosis, and Therapy. 2000). Male osteoporosis is a highly prevalent medical condition, with enormous impact on the health, medical-care expenditures, and quality of life of the aging U.S. male population. Race/ethnic-specific estimates of the prevalence of osteoporosis from population based. cross-sectional data are limited by: (1) Incomplete information on the range of variables that may be related to both bone density and race/ethnicity (e.g., bone turnover, hormone levels, lifestyle, nutrition, vitamin D status, and others) that might account for the racial/ethnic difference in prevalence; and (2) Limited data on Hispanics other than Mexican Americans, despite the well-known heterogeneity of ethnicities within Hispanic populations. The New England Research Institutes (NERI) has received an award from NIDDK to begin a large epidemiological research study of 3,000 randomly selected, community dwelling Hispanic, non-Hispanic African American, and non-Hispanic Caucasian men ages 40-79 years (1,000 per racial/ethnic group), to provide normative data on four urologic conditions. The proposed study will take advantage of this newly assembled cohort by adding a cross-sectional, population-based sub-study of bone density and osteoporosis in men. We will recruit 900 men from the parent study and describe the distribution of bone mineral density (BMD) and low BMD by race/ethnicity and determine to what extent variables (e.g., health status, lifestyle, sociodemographics, biochemical measures of bone turnover and hormone levels, fracture history) correlate with BMD, and whether the effect of these variables on BMD varies with race/ethnicity. To prepare for the possibility of a future, separately funded prospective study, we will initiate panel maintenance activities with the cohort. This design represents a cost-efficient approach to gathering detailed information focused on bone health in a randomly selected, population-based sample, while taking advantage of the activities currently underway as part of the parent study.