EFFECTS OF DIETARY SALT INTAKE ON INTESTINAL CYP3A4 & P GLYCOPROTEIN

我们已经表明，肠道表达的P-糖蛋白和CYP 3A 4和肝脏表达的CYP 3A 4能够解释高达75%的口服动力学的一些药物。最近有报道称，低盐饮食摄入增加了奎尼丁（一种常规使用的抗癫痫药）的口服吸收。由于奎尼丁是P-糖蛋白和CYP 3A 4的底物，我们假设盐的作用是由于P-糖蛋白和/或CYP 3A 4表达水平的变化。本研究将通过测量接受低盐和高盐饮食的受试者中奎尼丁的药代动力学和P-糖蛋白以及CYP 3A 4水平来直接检验这一假设。

We have shown that the intestinal expression of P-glycoprotein and CYP3A4 and the liver expression of CYP3A4 are able to explain up to 75% of the oral kinetics of some drugs. It was recently reported that low dietary salt intake increased to oral absorption of quinidine, a routinely used antiarrhythmic. Since quinidine is a substrate for both P-glycoprotein and CYP3A4, we hypothesize that the effect of salt is due to changes in the level of expression of P-glycoprotein and/or CYP3A4. This study will directly test this hypothesis by measuring quinidine pharmacokinetics and P-glycoprotein and CYP3A4 levels in subjects placed on low and high salt diets.