FEXOFENADINE AS A PROBE FOR ENTEROCYTE P GLYCOPROTEIN

肠内p -糖蛋白表达的患者间差异已被证明是口服环孢素A可变性的重要原因(1)。一种能够定量测定p -糖蛋白的探针检测方法，对于表征肠道p -糖蛋白个体间表达差异的遗传和非遗传因素，以及进一步确定p -糖蛋白在其他药物口服动力学中的作用具有重要价值。本研究将直接验证口服非索非那定（Allgra）可用于测定p -糖蛋白功能的假设。

Interpatient variation in expression of P-glycoprotein in the intestine has been shown to substantially contribute to the variability in the oral availability of cyclosporin A (1). A probe based test capable of quantitating P-glycoprotein would be very valuable in characterizing the genetic and non genetic factors that underlie interindividual variation in intestinal expression of P-glycoprotein and to further extablish the role of P-glycoprotein in the oral kinetics of other drugs. This study will directly test the hypothesis that orally administered fexofenadine (Allgra) can be used as an assay for P-glycoprotein function.