FEXOFENADINE AS A PROBE FOR ENTEROCYTE P GLYCOPROTEIN

患者间肠道P-糖蛋白表达的差异已被证明是环孢素A口服利用度差异的重要原因(1)。一种基于探针的P-糖蛋白定量检测方法对于确定P-糖蛋白肠道表达个体间差异的遗传和非遗传因素以及进一步阐明P-糖蛋白在其他药物口服动力学中的作用具有重要意义。这项研究将直接检验口服非索非那定(Allgra)可用作P-糖蛋白功能检测的假设。

Interpatient variation in expression of P-glycoprotein in the intestine has been shown to substantially contribute to the variability in the oral availability of cyclosporin A (1). A probe based test capable of quantitating P-glycoprotein would be very valuable in characterizing the genetic and non genetic factors that underlie interindividual variation in intestinal expression of P-glycoprotein and to further extablish the role of P-glycoprotein in the oral kinetics of other drugs. This study will directly test the hypothesis that orally administered fexofenadine (Allgra) can be used as an assay for P-glycoprotein function.