FEXOFENADINE AS A PROBE FOR ENTEROCYTE P GLYCOPROTEIN

非索非那定作为肠细胞 P 糖蛋白的探针

• 批准号: 6274788
• 负责人: KENNETH S LOWN
• 金额: $ 2.15万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6274788
• 关键词: P glycoprotein; antihistamines; bioassay; biomarker; clinical research; clinical trials; gastrointestinal drug absorption; gene expression; human subject; oral administration; pharmacokinetics; protein structure function

Interpatient variation in expression of P-glycoprotein in the intestine has been shown to substantially contribute to the variability in the oral availability of cyclosporin A (1). A probe based test capable of quantitating P-glycoprotein would be very valuable in characterizing the genetic and non genetic factors that underlie interindividual variation in intestinal expression of P-glycoprotein and to further extablish the role of P-glycoprotein in the oral kinetics of other drugs. This study will directly test the hypothesis that orally administered fexofenadine (Allgra) can be used as an assay for P-glycoprotein function.

肠内p -糖蛋白表达的患者间差异