FEXOFENADINE AS A PROBE FOR ENTEROCYTE P GLYCOPROTEIN

肠内P-糖蛋白表达的患者间差异 已被证明是在很大程度上有助于在变异性 环孢素A的口服利用度（1）。一种基于探针的测试， P-糖蛋白的定量在表征 个体间变异的遗传和非遗传因素 在肠道表达的P-糖蛋白，并进一步建立 P-糖蛋白在其他药物口服动力学中的作用。 本研究 将直接检验口服非索非那定 （Allgra）可用作P-糖蛋白功能的测定。

Interpatient variation in expression of P-glycoprotein in the intestine has been shown to substantially contribute to the variability in the oral availability of cyclosporin A (1). A probe based test capable of quantitating P-glycoprotein would be very valuable in characterizing the genetic and non genetic factors that underlie interindividual variation in intestinal expression of P-glycoprotein and to further extablish the role of P-glycoprotein in the oral kinetics of other drugs. This study will directly test the hypothesis that orally administered fexofenadine (Allgra) can be used as an assay for P-glycoprotein function.