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EFFECT OF AGE ON PANCREATIC BETA CELL RESPONSE TO CHANGES IN INSULIN SENSITIVITY

EFFECT OF AGE ON PANCREATIC BETA CELL RESPONSE TO CHANGES IN INSULIN SENSITIVITY
年龄对胰腺β细胞对胰岛素敏感性变化反应的影响
批准号：
6113462
负责人：
JEFFREY B. HALTER
金额：
$0.02万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6113462
关键词：
age difference aging clinical research glucose tolerance human old age (65+) human subject insulin insulin sensitivity /resistance nicotinate pancreatic islets pharmacokinetics secretion young adult human (21-34)

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中文摘要
翻译
人类的衰老与葡萄糖耐受和胰岛素敏感性的变化有关，但年龄对人类胰岛β细胞功能的影响尚不清楚。胰岛素敏感性可以被几种药物改变，曲格列酮就是其中之一，它可以增强胰岛素敏感性。我们建议研究年轻和老年受试者(有和没有糖耐量受损)服用曲格列酮前后的胰岛素分泌反应，以观察衰老对胰岛β细胞适应胰岛素敏感性增加的影响。
英文摘要
Human aging is associated with glucose intolerance and changes in insulin sensitivity but age effects on pancreatic beta cell function in humans are not clear. Insulin sensitivity can be changed by several pharmacological agents one of which is troglitazone which enhances insulin sensitivity. We propose to study insulin secretion responses of young and elderly subjects (with and without impaired glucose tolerance) before and after troglitazone administration to observe the effect aging has on pancreatic beta cell adaptation to increased insulin sensitivity.
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Summer Research Training in Aging for Medical Students
Summer Research Training in Aging for Medical Students
Summer Research Training in Aging for Medical Students
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