Tissue-resident macrophages and malignant progression of ovarian cancer

假设：该项目将验证TRM与播散性癌细胞之间的特定相互作用轴促进其恶性进展和侵袭性疾病发展的假设。目的：我们的目标是揭示这些相互作用的分子基础，这些相互作用可能反过来反映可行的临床靶点。方法：我们的方法包括深入的描述性研究以及实验模型的体内验证，目的是更好地定义TRM并确定新的治疗靶点。我们将在之前工作的基础上，在新的临床相关HGSC模型中使用平行单细胞分析来绘制TRM和癌细胞之间的分子对话。我们还将产生新的和独特的工具来探测TRM在这些模型中的功能，并验证它们在肿瘤进展中的作用。结果：这些研究将为TRM的促肿瘤功能提供新的见解，并揭示分子靶点，以支持TRM靶向治疗人类癌症的发展。

THypothesis: This project will test the hypothesis that specific axes of interaction between TRM and disseminated cancer cells promotes their malignant progression and the development of invasive disease. Objecitve: Our objective is to unravel the molecular basis of these interactions that may in turn reflect viable clinical targets. Approach: Our approach includes in-depth descriptive studies coupled with in vivo validation in experimental models, with the aim to achieve a finer definition of TRM and identify new therapeutic targets. We will build on our previous work and map the molecular dialogue between TRM and cancer cells using parallel single cell analysis in new clinically relevant models of HGSC. We will also generate new and unique tools to probe the function of TRM in these models and validate their roles in tumour progression. Outcome: These studies will provide new insights into the tumour-promoting functions of TRM and reveal molecular targets to support the development of TRM targeted therapies for human cancer.