ENDOSCOPIC SPHINCTEROTOMY FOR SPHINCTER OF ODDI DYSFUNCTION

内镜括约肌切开术治疗 ODDI 括约肌功能障碍

• 批准号: 6263686
• 负责人: MICHELLE A JEDNAK
• 金额: $ 0.02万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6263686
• 关键词: analgesia; bile ducts; biliary tract disorder; cholangiography; clinical research; endoscopy; human subject; human therapy evaluation; pain; pancreas imaging /visualization; quality of life

Endoscopic sphincterotomy (ES) has been shown to be an effective treat- ment for relieving biliary-type pain in patients with sphincter of Oddi dysfuntion defined by elevated baseline sphincter pressures at the time of endoscopic retrograde cholangiography (ERC). Recent studies suggest that sphincter of Oddi manometry is neither 100% sensitive nor specific in predicting response to ES; further the efficacy of ES in patients with clinical sphincter dysfunction and normal manometry is largely unstudied. We theorize that endoscopic sphincterotomy will result in significant pain alleviation and improved quality of life when compared to sham sphincterotomy in this previously unstudied patient population.

内镜下括约肌切开术（ES）已被证明是缓解Oddi括约肌功能障碍患者胆道型疼痛的有效治疗方法，该功能障碍的定义是内镜逆行胆道造影（ERC）时括约肌基线压力升高。最近的研究表明，Oddi括约肌测压在预测ES反应方面既不是100%敏感也不是100%特异性；此外，ES在临床括约肌功能障碍和血压正常的患者中的疗效在很大程度上尚未研究。我们推测，在这一之前未研究的患者群体中，与假括约肌切开术相比，内窥镜括约肌切开术将显著减轻疼痛并改善生活质量。