AGE EFFECT ON PANCREATIC BETA CELL RESPONSE TO CHANGES IN INSULIN SENSITIVITY

人类的衰老与葡萄糖耐受和胰岛素敏感性的变化有关，但年龄对人类胰岛β细胞功能的影响尚不清楚。在健康的年轻人中，胰岛β细胞功能通过增加对葡萄糖的敏感性来适应胰岛素抵抗，从而导致胰岛素分泌增加。几种药物可以改变胰岛素敏感性，烟酸就是其中之一，它可以诱导胰岛素抵抗并增强健康年轻人的胰岛素分泌反应。我们建议研究年轻和老年受试者(有和没有糖耐量受损)服用烟酸前后的胰岛素分泌反应，以验证衰老导致胰岛β细胞对胰岛素抵抗的适应性受损的假设。

Human aging is associated with glucose intolerance and changes in insulin sensitivity but age effects on pancreatic beta cell function in humans are not clear. In healthy young people pancreatic beta cell function adapts to insulin resistance by increasing sensitivity to glucose resulting in increased insulin secretion. Insulin sensitivity can be changed by several pharmacological agents one of which is nicotinic acid which induces insulin resistance and enhances insulin secretion responses in healthy young adults. We propose to study insulin secretion responses of young and elderly subjects (with and without impaired glucose tolerance) before and after nicotinic acid administration to test the hypothesis that aging causes impaired pancreatic beta cell adaptation to insulin resistance.