AGE EFFECT ON PANCREATIC BETA CELL RESPONSE TO CHANGES IN INSULIN SENSITIVITY

人类衰老与葡萄糖耐受不良和胰岛素敏感性的变化有关，但年龄对人类胰腺β细胞功能的影响尚不清楚。 在健康的年轻人中，胰腺β细胞功能通过增加对葡萄糖的敏感性来适应胰岛素抵抗，从而增加胰岛素分泌。 胰岛素敏感性可以通过几种药物改变，其中之一是烟酸，其在健康的年轻人中诱导胰岛素抵抗并增强胰岛素分泌反应。 我们建议研究烟酸给药前后年轻和老年受试者（有和没有糖耐量受损）的胰岛素分泌反应，以检验衰老导致胰腺β细胞适应胰岛素抵抗受损的假设。

Human aging is associated with glucose intolerance and changes in insulin sensitivity but age effects on pancreatic beta cell function in humans are not clear. In healthy young people pancreatic beta cell function adapts to insulin resistance by increasing sensitivity to glucose resulting in increased insulin secretion. Insulin sensitivity can be changed by several pharmacological agents one of which is nicotinic acid which induces insulin resistance and enhances insulin secretion responses in healthy young adults. We propose to study insulin secretion responses of young and elderly subjects (with and without impaired glucose tolerance) before and after nicotinic acid administration to test the hypothesis that aging causes impaired pancreatic beta cell adaptation to insulin resistance.