Development of sustainable academic-industry partnerships: Untapping breakthrough innovation for the treatment and management of infectious diseases

发展可持续的学术与产业伙伴关系：为传染病的治疗和管理探索突破性创新

• 批准号: MR/W004356/1
• 负责人: Giancarlo Biagini
• 金额: $ 10.86万
• 依托单位: Liverpool School of Tropical Medicine
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FW004356%2F1
• 关键词: Development; sustainable; academic; industry; partnerships

Infectious diseases represent a continuous and increasing threat to human health both nationally and internationally. In the UK, rapid increases in antimicrobial drug resistance (AMR) and recent experiences from the SARS-CoV-2 pandemic, highlight the need for investment in solutions to manage and eliminate these threats to human health. There is scope for optimism however as running parallel to these challenges, technological advancement and innovation are creating new opportunities for managing and mitigating against infectious disease crises. These include improved platforms for diagnostic, vaccine and therapeutics discovery, as well as advancements in disruptive technologies such as artificial intelligence (AI), the Internet of Things (IoT), Big Data, robotics and drone technology. It is clear from the current COVID-19 pandemic that academic partnerships with industry are key to quickly developing the required tools and the elimination of bottlenecks essential to addressing the health needs. Whilst it is broadly recognised that strengths in basic science reside in academia, it is the industrial sector that has the expertise and capability to bring innovations to market quickly.The largest cluster of infection-focused businesses in Europe is growing in the North West. In addition, the Liverpool City Region (LCR) has been identified in a 2017 BEIS-commissioned "LCR+" Science & Innovation Audit (SIA), to possess a concentration of "smart specialisation" opportunities in interrelated sectors of 4IR/advanced manufacturing, clean growth, digital and createch, and health and life sciences. Demonstrable and genuinely distinctive science and industry assets and capabilities include the Materials Innovation Factory, the STFC Hartree Centre supercomputer and the IBM Watson platform.The key challenge that forms the basis of this application is how to unlock the innovation potential of this unique scientific and industrial cluster to develop solutions that address the described health needs of existing and emerging infectious diseases.Aims &Objectives: Setting up links between academia and industry requires mutual trust, commitment, motivation and the creation of bilateral value through a common purpose. This can be challenging to set up as the two sectors generally have different goals and objectives and operate with different procedures and cultures.The overarching aim of this application is for the secondee to gain the relevant knowledge, experience and skills that will aid him in the development of a strategic road map and effective operational models that support the development of innovative solutions to current and emerging infectious disease-related health needs. Towards this aim, the specific objectives include:(i) To gain broader knowledge of the regional private sector scientific and industrial strengths, especially in disruptive technologies.(ii) To gain deeper knowledge and experience of effective enabling activities and operational models used to foster a climate of innovation between academia and industry.(iii) To gain a better understanding of the sector skills priorities and knowledge of effective mechanisms that facilitate career mobility.(iv) To gain a greater understanding of the role that academia can play to increase the productivity of industry and the impact that these relationships and investments make both regionally and nationally. Successful completion of this secondment has the potential to benefit both the secondee and the secondment organisation by fostering a sustainable partnership that (i) accelerates the generation of breakthrough innovations for the benefit of human health, (ii) results in upskilling of the workforce enabling sector mobility and (iii) impacts by increasing the productivity of the local and national economy. These outputs are directly aligned to the aims of the UKRI Innovation Secondment scheme.

传染病在国家和国际上对人类健康构成持续和日益严重的威胁。在英国，抗菌药物耐药性（AMR）的迅速增加和最近的SARS-CoV-2大流行的经验，突出了投资解决方案的必要性，以管理和消除这些对人类健康的威胁。然而，在应对这些挑战的同时，技术进步和创新正在为管理和缓解传染病危机创造新的机会，因此仍有乐观的余地。其中包括改进的诊断、疫苗和治疗发现平台，以及人工智能（AI）、物联网（IoT）、大数据、机器人和无人机技术等颠覆性技术的进步。从目前的COVID-19疫情中可以清楚地看到，学术界与产业界的合作是快速开发所需工具和消除瓶颈的关键，这些都是解决卫生需求所必需的。虽然人们普遍认为基础科学的优势在于学术界，但工业部门拥有将创新迅速推向市场的专业知识和能力。欧洲最大的以感染为重点的企业集群正在西北部发展。此外，利物浦城市地区（LCR）在2017年由BEIS委托进行的“LCR+”科学与创新审计（SIA）中被确定为在4 IR/先进制造、清洁增长、数字和生物技术以及健康和生命科学等相关领域拥有集中的“智能专业化”机会。材料创新工厂、STFC Hartree中心超级计算机和IBM沃森平台等可证明的、真正独特的科学和工业资产和能力构成了这一应用的基础，其关键挑战是如何释放这一独特的科学和工业集群的创新潜力，以开发解决现有和新出现的传染病所述健康需求的解决方案。建立学术界和工业界之间的联系需要相互信任、承诺、动力和通过共同目标创造双边价值。这可能是具有挑战性的设置，因为这两个部门通常有不同的目标和目的，并以不同的程序和文化运作。此应用程序的首要目标是让借调人员获得相关知识，经验和技能，这将有助于他制定一个战略路线图和有效的运作模式，支持开发创新的解决方案，以目前和新出现的传染病-相关的健康需求。为实现这一目标，具体目标包括：（i）更广泛地了解区域私营部门的科学和工业实力，特别是在颠覆性技术方面。(ii)获得更深入的知识和经验，有效的扶持活动和业务模式，用于促进学术界和工业界之间的创新气氛。(iii)更好地了解部门技能优先事项和促进职业流动的有效机制的知识。(iv)为了更好地了解学术界可以发挥的作用，以提高工业生产力和这些关系和投资的影响，使区域和国家。成功完成这一借调有可能通过促进可持续的伙伴关系使借调人员和借调组织受益，这种伙伴关系（i）加速产生有利于人类健康的突破性创新，（ii）提高劳动力的技能，使部门流动性和（iii）通过提高地方和国家经济的生产力产生影响。这些产出与UKRI创新借调计划的目标直接一致。

项目成果

A Quantitative Method for the Study of HIV-1 and Mycobacterium tuberculosis Coinfection.

• DOI: 10.1093/infdis/jiac491
• 发表时间: 2023-03-01
• 期刊: The Journal of infectious diseases

Antimicrobial Therapies - Methods and Protocols

抗菌疗法 - 方法和方案

• DOI: 10.1007/978-1-0716-1358-0_23
• 发表时间: 2021
• 作者: Donnellan S

Quantitation of tizoxanide in multiple matrices to support cell culture, animal and human research.

• DOI: 10.1101/2021.05.27.445500
• 发表时间: 2021-05
• 期刊: bioRxiv
• 作者: M. Neary;U. Arshad;Lee M. Tatham;H. Pertinez;H. Box;R. Rajoli;A. Valentijn;Joanne Sharp;S. Rannard;G. Biagini;P. Curley;A. Owen

SARS-CoV-2 infects an upper airway model derived from induced pluripotent stem cells.

• DOI: 10.1002/stem.3422
• 发表时间: 2021-10
• 期刊: Stem cells (Dayton, Ohio)
• 作者: Djidrovski I;Georgiou M;Hughes GL;Patterson EI;Casas-Sanchez A;Pennington SH;Biagini GA;Moya-Molina M;van den Bor J;Smit MJ;Chung G;Lako M;Armstrong L
• 通讯作者: Armstrong L

Attaching protein-adsorbing silica particles to the surface of cotton substrates for bioaerosol capture including SARS-CoV-2.

• DOI: 10.1038/s41467-023-40696-x
• 发表时间: 2023-08-18
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Collings, Kieran;Boisdon, Cedric;Sham, Tung-Ting;Skinley, Kevin;Oh, Hyun-Kyung;Prince, Tessa;Ahmed, Adham;Pennington, Shaun H.;Brownridge, Philip J.;Edwards, Thomas;Biagini, Giancarlo A.;Eyers, Claire E.;Lamb, Amanda;Myers, Peter;Maher, Simon
• 通讯作者: Maher, Simon