PULSATILE GH/PROLACTIN SECRETION IN NORMALS AND PATIENTS WITH PITUITARY ADENOMAS

正常人和垂体腺瘤患者的脉动 GH/催乳素分泌

• 批准号: 6115248
• 负责人: BAHA M ARAFAH
• 金额: $ 1.92万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6115248
• 关键词: adenoma; clinical research; human subject; neoplasm /cancer surgery; pituitary neoplasms; postoperative state; preoperative state; prolactin; secretion; somatotropin

The main goal of this project is to investigate the pulsatile nature of growth hormone and prolactin secretion in patients with pituitary adenomas. The relatively short half-life of these peptides in the circulation and the fact that they are secreted in pulses, limits interpretation of, and the physiologic significance of single hormone measurements. Recent studies have demonstrated the pulsatile nature of growth hormone and prolactin secretion in humans. Similar studies have not been conducted in patients with functioning or non functioning adenomas especially after surgical adenomectomy. We currently rely on pituitary hormone dynamic studies in the detailed evaluation of patients with adenomas and in assessing the long term outcome after surgery. While this approach has been very useful, the responses may not be representative of normal physiology. Investigating pulsatile hormone secretion in these patients should provide additional physiological significance to the dynamic studies. We have already determined the pulsatile pattern of hormone secretion in healthy individuals and will use the data for comparison to that of patients with pituitary adenomas. The current study will be limited to patients with adenomas, studied before or after surgery. Though limited, the data show pulsatile prolactin release in patients with adenomas. The pulse frequency was, however, decreased when compared to normal individuals. After successful surgical treatment, pulse frequency and amplitude are similar to normal. After surgery, there was a relative increase in nocturnal release of prolactin such that the ratio of night/day levels was similar to that of normal. A total of 11 patients with known pituitary adenomas have already been studied. Six were studied before surgery while five others were evaluated months to years postoperatively. Publication of the data will be delayed until more surgically treated patients are studied.

本项目的主要目的是研究垂体腺瘤患者生长激素和催乳素分泌的脉动性。这些肽在循环中的相对短的半衰期以及它们以脉冲形式分泌的事实限制了对单一激素测量的解释和生理学意义。 最近的研究已经证明了人类生长激素和催乳素分泌的脉动性质。 类似的研究还没有在功能性或非功能性腺瘤患者中进行，特别是在腺瘤切除术后。目前，我们依靠垂体激素动态研究对腺瘤患者进行详细评估，并评估手术后的长期结果。 虽然这种方法非常有用，但反应可能不代表正常生理。 研究这些患者的脉冲性激素分泌应该为动态研究提供额外的生理意义。 我们已经确定了健康个体激素分泌的脉动模式，并将使用这些数据与垂体腺瘤患者进行比较。 目前的研究将仅限于腺瘤患者，在手术前或手术后进行研究。虽然有限，但数据显示腺瘤患者存在脉冲性泌乳素释放。 然而，与正常人相比，脉搏频率降低。 手术治疗成功后，脉搏频率和振幅与正常相似。 手术后，催乳素的夜间释放相对增加，使得夜间/白天水平的比率与正常水平相似。总共有11例已知的垂体腺瘤已经进行了研究。 其中6例在术前进行了研究，另外5例在术后数月至数年进行了评估。 数据的发表将推迟到更多的手术治疗的患者进行研究。