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HUMAN PROLACTIN SECRETION IN VARIOUS ENDOCRINE DISORDERS

各种内分泌疾病中的人类催乳素分泌

基本信息

批准号：
6305469
负责人：
BAHA M ARAFAH
金额：
$ 1.92万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-12-01 至 2000-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6305469
关键词：
adenoma clinical research endocrine disorder endocrine surgery human subject hyperprolactinemia hypopituitarism neoplasm /cancer surgery pituitary neoplasms postoperative state preoperative state prolactin secretion

项目摘要

Prolactin levels are determined in patients with pituitary dysfunction during dynamic provocative stimulation. The emphasis is on patients with prolactin secreting pituitary adenomas, pre and post surgical adenomectomy. Patients with hyperprolactinemia and hypopituitarism are also being studied under this protocol. The dynamic studies in the latter group is likely to help define the mechanism of hypopituitarism in these patients. The data documenting the usefulness of prolactin dynamic studies in predicting the long term benefit from transsphenoidal surgery in patients with prolactin secreting pituitary adenomas were published in 1986. Prolactin levels are often elevated in patients with functioning or non functioning adenomas associated with hypopituitarism. Our study has demonstrated that the degree of prolactin level elevation under these situations, correlate with the potential for recovery of pituitary function after decompressive surgery. We are in the process of comparing and contrasting data on the dynamics of prolactin secretion with that obtained from evaluating the pulsatile aspect of prolactin secretion in the same patients. The long term follow up of patients who had surgical resection of pituitary adenomas 10 to 25 years ago, is being assessed. We have a major advantage in following a relatively large number of these patients to allow us to do these long-term studies.

在动态激发刺激期间测定垂体功能障碍患者的催乳素水平。重点是泌乳素分泌型垂体腺瘤患者、腺瘤切除术前后的患者。患有高催乳素血症和垂体功能减退症的患者也在该方案下进行研究。后一组的动态研究可能有助于确定这些患者垂体功能减退的机制。 1986 年发表的数据记录了催乳素动态研究在预测垂体催乳素腺瘤患者经蝶手术的长期获益方面的有用性。垂体功能减退相关的功能性或无功能性腺瘤患者的催乳素水平通常升高。我们的研究表明，在这些情况下催乳素水平升高的程度与减压手术后垂体功能恢复的潜力相关。我们正在将催乳素分泌动态数据与评估同一患者催乳素分泌脉动方面获得的数据进行比较和对比。目前正在评估 10 至 25 年前接受垂体腺瘤手术切除的患者的长期随访情况。我们的一个主要优势是跟踪相对大量的患者，使我们能够进行这些长期研究。