LIPOLYTIC SENSITIVITY & RESPONSE TO FASTING IN NORMO & HYPERTENSIVE OBESE HUMANS

脂质动力学的异常可能有助于增加 高血压病患者胰岛素抵抗和高脂血症的患病率 与血压正常的肥胖者相比。 因此，我们评估了 甘油在血浆中的出现率（a），全身指标 脂解活性，在基础条件和60分钟的 6例正常血压者禁食12 h和84 h后输注肾上腺素 高血压肥胖者6例。 脂肪细胞释放的甘油可以 通过稳定同位素稀释质谱法进行研究， 脂肪分解的标志物。 数据表明，脂肪氧化，基础 全身脂肪分解活性，以及对 与正常血压相比，高血压患者肾上腺素减弱 肥胖的人。

Abnormalities in lipid kinetics may contribute to the increased prevalence of insulin resistance and hyperlipidemia in hypertensive compared with normotensive obese persons. Therefore, we evaluated glycerol rate of appearance (a) in plasma, an index of whole-body lipolytic activity, during basal conditions and 60 minutes of epinephrine infusion after 12 h and 84 h of fasting in 6 normotensive and 6 hypertensive obese persons. Glycerol release from fat cells can be studied by stable isotope dilution mass spectrometry and is a marker of lipolysis. The data demonstrate that fat oxidation, basal whole-body lipolytic activity, and the lipolytic response to epinephrine are blunted in hypertensive compared with normotensive obese persons.