LIPOLYTIC SENSITIVITY & RESPONSE TO FASTING IN NORMO & HYPERTENSIVE OBESE HUMANS

脂肪分解敏感性

• 批准号: 6118599
• 负责人: Raymond R Townsend
• 金额: $ 0.4万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6118599
• 关键词: biomedical resource; cardiovascular system; female; human subject; lipids; male; spectrometry

Abnormalities in lipid kinetics may contribute to the increased prevalence of insulin resistance and hyperlipidemia in hypertensive compared with normotensive obese persons. Therefore, we evaluated glycerol rate of appearance (a) in plasma, an index of whole-body lipolytic activity, during basal conditions and 60 minutes of epinephrine infusion after 12 h and 84 h of fasting in 6 normotensive and 6 hypertensive obese persons. Glycerol release from fat cells can be studied by stable isotope dilution mass spectrometry and is a marker of lipolysis. The data demonstrate that fat oxidation, basal whole-body lipolytic activity, and the lipolytic response to epinephrine are blunted in hypertensive compared with normotensive obese persons.

脂质动力学的异常可能是导致 高血压病患者胰岛素抵抗和高脂血症的患病率 与血压正常的肥胖者相比。因此，我们评估了 甘油在血浆中的出现率(A)，一个全身的指标 基础状态下和60分钟内的脂解活性 6例正常血压患者禁食12h和84h后注射肾上腺素 高血压肥胖者6例。脂肪细胞释放甘油可以 用稳定同位素稀释质谱仪进行研究，是一种 脂肪分解的标志物。数据表明，脂肪氧化，基础 全身的脂解活性，以及对 与正常血压相比，高血压患者的肾上腺素是钝化的 肥胖者。