DEVELOPMENT OF A HIGH RESOLUTION NMR SCATTERING SYSTEM

高分辨率核磁共振散射系统的开发

• 批准号: 6279733
• 负责人: MARCO PRAVIA
• 金额: $ 0.12万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6279733
• 关键词: bioengineering /biomedical engineering; biomedical resource; nucleic acids; proteins; technology /technique

NMR scattering based on spin coherence transport mediated through dipolar interactions is a new field that we are developing. To make a meaningful measurement a magnetization grating must be created across the sample with a pitch comparable to the interspin distance of a dipolarly coupled spin pair. This demands gradient fields in excess of i04 G/cm. We have developed a means of creating pulsed gradients that can be finely controlled and which will deliver a magnetic field gradient of 100,000 G/cm at 1,000 A. We have also developed a robust switching circuit that delivers controllable current pulses at these levels. Important characteristics are fast switching times, repeatability and the stability of the gradient system in a strong background field. Over the past year we have rebuilt the spectrometer to improve the resolution of the pulse programmer and the spectral purity. Also the probe has been rebuilt to include a gomometer.

基于自旋相干输运的核磁共振散射 偶极相互作用是我们正在开发的一个新领域。要做一件 有意义的测量必须创建磁化光栅横跨 节距与旋转间距相当的样品 偶极耦合自旋对。这需要过多的梯度场 104G/cm。我们已经开发出一种创建脉冲梯度的方法 它可以很好地控制，并将提供一个磁场 在1000 A时的梯度为100,000 G/cm。我们还开发了一种强大的 一种开关电路，可在这些位置提供可控的电流脉冲 级别。重要的特征是快速切换时间， 强子空间中梯度系统的重复性和稳定性 背景场。在过去的一年里，我们已经重建了分光计 为了提高脉冲编程器和光谱的分辨率 纯洁。此外，探测器也进行了改造，包括一个GoMoMeter。