SKELETAL REGULATION IN CHILDREN WITH CHRONIC RENAL FAILURE

慢性肾功能衰竭儿童的骨骼调节

• 批准号: 6118464
• 负责人: ISIDRO B. SALUSKY
• 金额: $ 0.19万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6118464
• 关键词: 1,25 dihydroxycholecalciferol; bone disorder; child (0-11); chronic renal failure; clinical research; clinical trials; hormone regulation /control mechanism; human subject; human therapy evaluation; kidney function; parathyroid gland; parathyroid hormones; pathologic process; vitamin therapy

Bone disease is a frequent complication in patients with chronic renal failure. Growth retardation is a prominent clinical feature in most patients, and bone disease contributes substantially to the delay in skeletal development. Patients who develop renal failure early in childhood commonly have body height two standard deviations below the age-adjusted normal values and the major decline occurs within the first two years of life.

骨病是慢性肾衰竭患者常见的并发症。 生长迟缓是大多数患者的突出临床特征，并且骨骼疾病在很大程度上导致骨骼发育延迟。 在儿童早期发生肾衰竭的患者的身高通常比年龄调整的正常值低两个标准差，并且主要下降发生在生命的前两年。