PHOTON FLUORESCENCE IMAGE:CAMPTOTHECIN ANTICANCER DRUGS & CARRIER AT TUMOR SITES
PHOTON FLUORESCENCE IMAGE:CAMPTOTHECIN ANTICANCER DRUGS & CARRIER AT TUMOR SITES
批准号:
6220407
负责人:
THOMAS G BURKE
金额:
$0.42万
依托单位国家:
美国
项目类别:
财政年份:
1999
资助国家:
美国
项目状态:
已结题
起止时间:
1999-04-01 至 2000-03-31
中文摘要
我们已经开始使用LAMMP的双光子显微镜进行研究
英文摘要
We have begun to use the two-photon microscope at LAMMP to study
FDA approved anticancer agents, Camptothecin derivatives, in single
glioblastoma cells. To further characterize the cellular pharmacology
of this new class of highly lipophilic camptothecins, we have studied
the differential interactions of water-soluble versus highly
lipophilic camptothecins (DB67) with human glioblastoma cells. Images
obtained using two-photon microscopy of glioblastoma cells show a
clear correlation with between drug lipophilicity and drug
fluorescence levels achieved in the cells. Very high levels of
staining were achieved with highly lipophilic DB67, and levels fell
off with decreasing drug lipophilicity. Our data indicate that DB67
can extensively interact with the glioblastoma cells, and other cell
lines are now being studied as well. Future studies will involve
characterizing camptothecin interactions with a variety of cancer
cells and tumor spheroids using the two-photon micro sco py
technology. It will be interesting to compare how HSA modulates the
cellular accumulation of a protein-interactive drug such as
camptothecin versus a drug with reduced interactions such as the new
experimental analog DB-67.
期刊论文(0)
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科研奖励(0)
会议论文
PREFERENTIAL BINDING OF CARBOXYLATE FORM OF CAMTOTHECIN BY HUMAN SERUM ALBUMIN
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批准号:6978297
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项目类别:
-
资助金额:$1.1万
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财政年份:2004
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负责人:THOMAS G BURKE
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依托单位:
Combinatorial Development of Blood Stable Camptothecins
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批准号:6333194
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项目类别:
-
资助金额:$31.92万
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财政年份:2001
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负责人:THOMAS G BURKE
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依托单位:
FLUORESCENCE DETECTION OF ANTI CANCER DRUG TOPOTECAN
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批准号:6444723
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项目类别:
-
资助金额:$29.31万
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财政年份:2001
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负责人:THOMAS G BURKE
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依托单位:
PREFERENTIAL BINDING OF CARBOXYLATE FORM OF CAMTOTHECIN BY HUMAN SERUM ALBUMIN
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批准号:6444722
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项目类别:
-
资助金额:$29.31万
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财政年份:2001
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负责人:THOMAS G BURKE
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依托单位:
Potent Topoisomerase I Inhibition For Glioma Therapy
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批准号:6337830
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项目类别:
-
资助金额:$13.31万
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财政年份:2001
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负责人:THOMAS G BURKE
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依托单位:
FLUORESCENCE DETECTION OF ANTI CANCER DRUG TOPOTECAN
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批准号:6315389
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项目类别:
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资助金额:$2.83万
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财政年份:2000
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负责人:THOMAS G BURKE
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依托单位:
1 & 2 PHOTON FLUORESCENCE IMAGE CAMPTOTHECIN ANTICANCER DRUGS & DRUG CARRIERS
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批准号:6308191
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项目类别:
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资助金额:$2.46万
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财政年份:2000
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负责人:THOMAS G BURKE
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依托单位:
PREFERENTIAL BINDING OF CARBOXYLATE FORM OF CAMTOTHECIN BY HUMAN SERUM ALBUMIN
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批准号:6315388
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项目类别:
-
资助金额:$2.83万
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财政年份:2000
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负责人:THOMAS G BURKE
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依托单位:
COMBINATORIAL DEVELOPMENT OF ANTICANCER SILATECANS
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批准号:6014855
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项目类别:
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资助金额:$10.0万
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财政年份:2000
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负责人:THOMAS G BURKE
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依托单位:
PREFERENTIAL BINDING OF CARBOXYLATE FORM OF CAMTOTHECIN BY HUMAN SERUM ALBUMIN
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批准号:6122885
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项目类别:
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资助金额:$2.55万
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财政年份:1999
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负责人:THOMAS G BURKE
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依托单位:
FLUORESCENCE DETECTION OF ANTI CANCER DRUG TOPOTECAN
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批准号:6122886
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项目类别:
-
资助金额:$2.55万
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财政年份:1999
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负责人:THOMAS G BURKE
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依托单位:
1 & 2 PHOTON FLUORESCENCE IMAGE CAMPTOTHECIN ANTICANCER DRUGS & DRUG CARRIERS
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批准号:6119308
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项目类别:
-
资助金额:$2.46万
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财政年份:1999
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负责人:THOMAS G BURKE
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依托单位:
FLUORESCENCE DETECTION OF ANTI CANCER DRUG TOPOTECAN
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批准号:6282889
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项目类别:
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资助金额:$2.55万
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财政年份:1998
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负责人:THOMAS G BURKE
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依托单位:
Long Circulating Liposomal Camptothecins CAP and EAP
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批准号:6409473
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项目类别:
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资助金额:$28.4万
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财政年份:1998
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负责人:THOMAS G BURKE
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依托单位:
1 & 2 PHOTON FLUORESCENCE IMAGE CAMPTOTHECIN ANTICANCER DRUGS & DRUG CARRIERS
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批准号:6280329
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项目类别:
-
资助金额:$0.26万
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财政年份:1998
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负责人:THOMAS G BURKE
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依托单位:
PREFERENTIAL BINDING OF CARBOXYLATE FORM OF CAMTOTHECIN BY HUMAN SERUM ALBUMIN
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批准号:6282888
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项目类别:
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资助金额:$2.55万
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财政年份:1998
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负责人:THOMAS G BURKE
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依托单位:
STABLE CAMPTOTHECIN FORMULATIONS FOR CANCER TREATMENT
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批准号:2642020
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项目类别:
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资助金额:$10.0万
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财政年份:1998
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负责人:THOMAS G BURKE
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依托单位:
HUMAN SERUM ALBUMIN CAMPTOTHECIN CARBOXYLATE FORM BINDING: COLON CANCER
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批准号:6253903
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项目类别:
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资助金额:$4.01万
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财政年份:1997
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负责人:THOMAS G BURKE
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依托单位:
LIPOPHILIC CAMPTOTHECINS FOR CANCER TREATMENT
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批准号:2105634
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项目类别:
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资助金额:$18.15万
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财政年份:1994
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负责人:THOMAS G BURKE
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依托单位:
LONG-CIRCULATING LIPOSOMAL CAMPTOTHECINS
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批准号:2907996
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项目类别:
-
资助金额:$27.5万
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财政年份:1994
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负责人:THOMAS G BURKE
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依托单位:
海外基金