EFFECTS OF RELAXAT ANISOTROPY ON APPARENT DIFFUSION TENSOR IN COLLAGENOUS TISSUE

松弛各向异性对胶原组织表观弥散张量的影响

• 批准号: 6220747
• 负责人: SHENA H PARK
• 金额: $ 0.75万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-15 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6220747
• 关键词: Mammalia; biomedical resource; environmental toxicology; human tissue; model design /development; nuclear magnetic resonance spectroscopy; skin

The search for precise morphometric measurements of the different layers of the skin and a way to observe 3 dimensional changes upon cutaneous application of toxic chemical have lead to the idea that MRM might be able to bring new information to the field This project is designed as preliminary work , to determine if MRM is indeed suitable for skin research. This preliminary work will include: development and adaptation of MR probe and pulse sequences for skin imaging; MR imaging of formalin-fixed skin and ultimately imaging of skin on a live rat under anesthesia. Fixed skin specimen will be obtained post-mortem from control rat, mice or guinea pig of other ongoing studies. In vivo imaging is anticipated on rats only.

寻找不同的精确形态测量 皮肤层和一种观察三维变化的方法， 有毒化学物质的皮肤应用导致了MRM 也许能给这个领域带来新的信息。 设计作为初步工作，以确定MRM是否确实适用 皮肤研究。 这项初步工作将包括： 以及用于皮肤成像的MR探头和脉冲序列的适配; 福尔马林固定的皮肤的成像以及最终在 麻醉下的活大鼠。 将获得固定的皮肤标本 其他正在进行的对照大鼠、小鼠或豚鼠尸检 问题研究 预期仅在大鼠上进行体内成像。