EFFECTS OF RELAXAT ANISOTROPY ON APPARENT DIFFUSION TENSOR IN COLLAGENOUS TISSUE

松弛各向异性对胶原组织表观弥散张量的影响

• 批准号: 6493757
• 负责人: SHENA H PARK
• 金额: $ 28.8万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6493757
• 关键词: Mammalia; biomedical resource; environmental toxicology; human tissue; model design /development; nuclear magnetic resonance spectroscopy; skin

The search for precise morphometric measurements of the different layers of the skin and a way to observe 3 dimensional changes upon cutaneous application of toxic chemical have lead to the idea that MRM might be able to bring new information to the field This project is designed as preliminary work , to determine if MRM is indeed suitable for skin research. This preliminary work will include: development and adaptation of MR probe and pulse sequences for skin imaging; MR imaging of formalin-fixed skin and ultimately imaging of skin on a live rat under anesthesia. Fixed skin specimen will be obtained post-mortem from control rat, mice or guinea pig of other ongoing studies. In vivo imaging is anticipated on rats only.

寻找不同形状的物体的精确测量方法 皮肤的层次和一种观察三维变化的方法 皮肤应用有毒化学品导致了MRM的想法 可能会给这个项目领域带来新的信息 设计为初步工作，以确定MRM是否确实适合 用于皮肤研究。这项前期工作将包括：开发 和用于皮肤成像的MR探针和脉冲序列的适配； 福尔马林固定皮肤的成像，并最终在 麻醉下的活大鼠。将获得固定的皮肤样本 对照大鼠、小鼠或正在进行的其他动物的身体解剖 学习。体内成像仅适用于大鼠。