DIFFUSION TENSOR MEASUREMENT OF GUINEA PIG LUNG AIRWAYS USING HYPERPOLARIZED 3HE

使用超极化 3HE 测量豚鼠肺气道的扩散张量

• 批准号: 6220709
• 负责人: X J CHEN
• 金额: $ 2.25万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-15 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6220709
• 关键词: Mammalia; biomedical equipment development; biomedical resource; human tissue; model design /development; nuclear magnetic resonance spectroscopy; technology /technique

To develop specific techniques for in vivo imaging of the mouse with MR microscopy. This will primarily involve determining animal handling procedures, ventilation, and anesthesia requirements for imaging. This work with the normal mouse is in preparation for future studies using mice for developmental and toxicologic studies. The mouse has been used extensively as a model for many pathologies and in genetic studies. the use of higher resolution MR microscopes such as our 9 T system for in vivo imaging requires that the animal be no bigger than a 20 to 30 g mouse. Currently, we are not able to image this small an animal because of the limitation of our animal support and monitoring systems. This project proposes to solve these problems and make it possible to do non-invasive, survival imaging of mice. This capability of imaging such small animals will make it possible to do many important basic and applied in vivo studies in this important research animal.

开发小鼠体内成像的特定技术 用MR显微镜。 这主要涉及确定动物 处理程序、通气和麻醉要求， 显像 这项针对普通老鼠的研究是为将来的实验做准备 使用小鼠进行发育和毒理学研究。 的 小鼠已被广泛用作许多病理学的模型， 基因研究。 使用更高分辨率的MR显微镜， 我们的9 T系统用于体内成像，要求动物没有 比20到30克重的老鼠还要大。 目前，我们无法想象 由于我们对动物的支持有限， 和监控系统。 本项目拟解决这些问题 并使其能够对小鼠进行非侵入性的存活成像。 这种对这种小动物成像的能力将使我们有可能 做了许多重要的基础和应用在体内研究，在这个重要的 研究动物