DIFFUSION TENSOR MEASUREMENT OF GUINEA PIG LUNG AIRWAYS USING HYPERPOLARIZED 3HE

使用超极化 3HE 测量豚鼠肺气道的扩散张量

• 批准号: 6493719
• 负责人: X J CHEN
• 金额: $ 28.8万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6493719
• 关键词: Mammalia; biomedical equipment development; biomedical resource; human tissue; model design /development; nuclear magnetic resonance spectroscopy; technology /technique

To develop specific techniques for in vivo imaging of the mouse with MR microscopy. This will primarily involve determining animal handling procedures, ventilation, and anesthesia requirements for imaging. This work with the normal mouse is in preparation for future studies using mice for developmental and toxicologic studies. The mouse has been used extensively as a model for many pathologies and in genetic studies. the use of higher resolution MR microscopes such as our 9 T system for in vivo imaging requires that the animal be no bigger than a 20 to 30 g mouse. Currently, we are not able to image this small an animal because of the limitation of our animal support and monitoring systems. This project proposes to solve these problems and make it possible to do non-invasive, survival imaging of mice. This capability of imaging such small animals will make it possible to do many important basic and applied in vivo studies in this important research animal.

开发小鼠体内成像的特定技术 用 MR 显微镜。 这主要涉及确定动物 处理程序、通风和麻醉要求 成像。 这项与普通鼠标的工作是为将来做准备 使用小鼠进行发育和毒理学研究的研究。 这 小鼠已被广泛用作许多病理学的模型 遗传学研究。 使用更高分辨率的 MR 显微镜，例如 我们的 9 T 体内成像系统要求动物不 比 20 至 30 克的鼠标大。 目前，我们无法成像 由于我们的动物支持有限，这种动物很小 和监控系统。 该项目旨在解决这些问题 并使对小鼠进行非侵入性生存成像成为可能。 这种对此类小动物进行成像的能力将使 在这个重要的领域进行许多重要的基础和应用体内研究 研究动物。