LOCALIZED MEASUREMENTS OF HYPERPOLARIZED 3HE DIFFUSION & T2* IN GUINEA PIG LUNG

超极化 3HE 扩散的局部测量

• 批准号: 6282314
• 负责人: X J CHEN
• 金额: $ 1.33万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6282314
• 关键词: Mammalia; biomedical resource; human tissue; magnetic resonance imaging; model design /development; respiratory system; technology /technique

The diffusion of 3He in the live guinea pig lung will be studied with various methods. The time evolution of a slice profile will give an average measure of the diffusion with 2D spatial localization. Diffusion weighted imaging with radial acquisition will give another average measure. Spectroscopic studies with spatially selective RF pulses should give more quantitative data. In addition, measurements of T2* will be accomplished by taking successive projection reconstruction images and varying the acquisition delay.

本文研究了~ 3 He在活体豚鼠肺中的扩散 用不同的方法。 切片剖面的时间演变将给出 具有2D空间定位的扩散的平均测量。 弥散加权成像与径向采集将给出另一个 平均尺度。 空间选择性射频光谱研究 脉冲应该提供更多的定量数据。 此外，测量 T2* 将通过连续投影来实现 重建图像和改变采集延迟。