LOCALIZED MEASUREMENTS OF HYPERPOLARIZED 3HE DIFFUSION & T2* IN GUINEA PIG LUNG

超极化 3HE 扩散的局部测量

• 批准号: 6122279
• 负责人: X J CHEN
• 金额: $ 0.05万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-02-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6122279
• 关键词: Mammalia; bioimaging /biomedical imaging; biomedical resource; human tissue; magnetic resonance imaging; model design /development; respiratory system; technology /technique

The diffusion of 3He in the live guinea pig lung will be studied with various methods. The time evolution of a slice profile will give an average measure of the diffusion with 2D spatial localization. Diffusion weighted imaging with radial acquisition will give another average measure. Spectroscopic studies with spatially selective RF pulses should give more quantitative data. In addition, measurements of T2* will be accomplished by taking successive projection reconstruction images and varying the acquisition delay.

将研究 3He 在活体豚鼠肺中的扩散 用各种方法。 切片剖面的时间演化将给出 二维空间定位扩散的平均测量。 具有径向采集的扩散加权成像将提供另一个 平均测量。 空间选择性射频的光谱研究 脉冲应该提供更多的定量数据。 此外，测量 T2* 的值将通过连续投影来完成 重建图像并改变采集延迟。