CORE RESEARCH GRANT

核心研究补助金

• 批准号: 6220986
• 负责人: BRUCE G. BUCHANAN
• 金额: $ 2.49万
• 依托单位: MELLON PITTS CORPORATION (MPC CORP)
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6220986
• 关键词: bioengineering /biomedical engineering; biomedical resource; skeletal system

This computational work addresses three orthopedic research problems: simulating bone adaptation around an implant; calculating electric fields induced in bone by exogenous magnetic fields; and quantifying fluid flow in a mechanically loaded bone. Simulating bone adaptation is accomplished by applying physiological loads and constraints to a finite element model of the canine distal femur and using a bone remodeling finite element program to model the changes in porosity and architecture of the bone surrounding an implant experimentally inserted in the femur. The remodeling finite element code has successfully been used on the C90, and additional runs are needed to further explore the effects of different loading conditions on the resulting bone adaptation. The electric field problem is part of a project that is aimed at relating bone adaptation to electric field intensity to find a relationship between the applied fields and the biological response in a turkey model. Codes utilizing the finite element method and the finite difference method will be explored to find an optimal way to quantify the induced electric fields in a turkey wing that is exposed to a time-varying magnetic field. For the problem of fluid flow in bone, the interaction between the bone fluid and the bone matrix will be investigated using a finite element model also based upon a turkey model. First a finite element model of a bone mechanically loaded to mimic experimental loading conditions will be run to calculate displacements and strains on the bone-organ level. These displacements and strains will then be used as boundary conditions for a bone-tissue model that includes the small bone channels through which bone fluid flows. A finite element code that induces fluid-structure interaction will be investigated.

这项计算工作涉及三个骨科研究 问题：模拟植入物周围的骨适应;计算 由外源磁场在骨中诱导的电场;以及 量化机械加载的骨中的流体流动。 模拟骨 通过施加生理负荷来实现适应， 对犬股骨远端有限元模型的约束， 使用骨重建有限元程序来模拟 植入物周围骨的孔隙率和结构 实验性地植入股骨 重构有限元 代码已成功用于C90，其他运行是 需要进一步探索不同加载条件的影响 对骨骼适应性的影响。 电场问题是 一个旨在将骨骼适应性与电 场强度，以找到所施加的场与 火鸡模型中的生物反应 代码利用有限 有限元法和有限差分法将被探索， 找到一种最佳的方法来量化感应电场， 暴露在时变磁场中的火鸡翅膀。 为 骨内流体流动的问题，骨液之间的相互作用 并将使用有限元模型研究骨基质 也是基于火鸡模型。 首先建立了一个有限元模型， 模拟实验载荷条件的机械载荷骨将 来计算骨器官水平上的位移和应变。 然后将这些位移和应变用作边界 包括小骨的骨组织模型的条件 骨液流过的通道。 有限元代码， 引起的流体-结构相互作用将进行研究。