SEQUENCE CONSIDERATIONS IN SINGLE SHOT SPIRAL FAIR IMAGING

导言：在1996-97年间，我们进行了一项初步研究，以 评价磁共振在研究软骨细胞术后变化中的作用 移植，一种最近描述的过程，可能会导致 关节软骨损伤后的重建 受伤或骨关节炎。方法/结果：我们评估了几种磁共振 旨在表征软骨和潜在骨髓的序列 信号的变化，以及移植的轮廓变化。这些 包括快速自旋回波、SSMT和光谱序列 由加里·戈尔德博士开发。第一个经历了 软骨细胞移植程序(Carticel；Genzyme，Inc.)在斯坦福大学 在接下来的一年里，每3-4个月进行一次磁共振检查， 其他一些患者也做了磁共振检查。我们正在计划 在Carticel手术后2年内检查了12名患者， 由Genzyme支持，并使用下的其他软骨MR序列 发展，如扩散成像，以研究这些 病人。结论：我们已经证明了关节下骨髓 软骨细胞移植后几个月内浮肿消失 移植，局灶性软骨表面光滑。 已经处理过的缺陷。

Introduction: During 1996-97 we performed a pilot study to evaluate how well MR can be used to study changes after a chondrocyte transplantation, a recently described procedure that may lead to reconstitution of articular cartilage which has been damaged by an injury or osteoarthritis. Methods/Results: We evaluated several MR sequences aimed at characterizing cartilage and underlying bone marrow signal changes, as well as contour changes of the transplant. These have included fast spin-echo, SSMT, and a spectroscopy sequence developed by Dr. Garry Gold. The first person to undergo the chondrocyte transplant procedure (Carticel; Genzyme, Inc.) at Stanford has been followed with MR exams performed every 3-4 months for a year, and a few other patients have had MR exams as well. We are planning to examine 12 patients over 2 years post-Carticel procedure, with support from Genzyme, and use other cartilage MR sequences under development as well, such as diffusion imaging, to study these patients. Conclusions: We have shown that subarticular bone marrow edema disappeared within a few months after the chondrocyte transplant, and a smooth surface was formed over the focal cartilage defect that was treated.