Genes & Health Longitudinal Population Study

基因

• 批准号: MR/X009920/1
• 负责人: Sarah Finer
• 金额: $ 259.05万
• 依托单位: Queen Mary University of London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FX009920%2F1
• 关键词: Genes; Health; Longitudinal; Population; Study

Genes & Health is a large study involving British Bangladeshi and Pakistani people in health research. People from these backgrounds experience higher rates of ill health compared to White Europeans (e.g. type 2 diabetes and cardiovascular disease are four times and twice as common, respectively). The health inequalities faced by British south Asians are further exacerbated by their underrepresentation in health and genomic research. For example, only ~2% of participants in global genome-wide association studies (one of the commonest types of genetic study) are south Asian despite making up ~25% of the world's population. Genes & Health is succeeding in redressing some of this imbalance and is proving a valuable contributor to the global research stage.Since it started in 2015, Genes & Health has managed to recruit 50,455 volunteers, through extensive and lasting engagement with the communities it represents. Genes & Health exists as a scientific resource available for a global research community to use, thereby ensure that the greatest benefits to health are achieved from the contributions of these volunteers. Through the research that Genes & Health has already supported, it has already had several major impacts, including:i. Discovering how complete gene knockouts contribute to health and diseaseii. Supporting development of a new drug (Lumasiran) for a rare genetic disease causing severe ill-health in childreniii. A significant contribution to a consortium uncovering how our genes make us more susceptible to developing, or getting unwell from, COVID-19iv. Improving the prediction of who is at risk of developing type 2 diabetes using genetic datav. Uncovering a new biological pathway involved in childhood growth and pubertyDespite these early successes, Genes & Health is now at a critical phase, with its sustainability and potential for growth uncertain. With funding from the MRC Longitudinal Population Study scheme, Genes & Health will be able to sustain itself as a long-term study of health and disease in this underrepresented population of British south Asians, working together with other valuable research cohort studies for maximal benefit. This funding will also allow Genes & Health to grow and better address areas of health need which remain unmet, including mental health and pregnancy health. Our proposal focuses on the following areas:1. Supporting the overall sustainability of Genes & Health through support of its core research team, beyond the duration of its current infrastructure funding, and to generate rich longitudinal data.2. Delivering growth of Genes & Health 'recall' studies, where its existing volunteers are invited to participate in additional research, and where significant added value lies3. Expanding data collection in mental health and pregnancy, to address areas of unmet health need4. Growing the Genes & Health data resource to ensure it can be aligned to other cohort research studies to ensure analyses that are greater than the sum of their parts.To do this, we seek additional funding, which will support the input of some additional senior academic experts, and an expanded team of individuals to deliver our ambition.

基因与健康是一项涉及英国、孟加拉国和巴基斯坦人参与健康研究的大型研究。与欧洲白人相比，这些背景的人健康状况不佳的几率更高(例如，2型糖尿病和心血管疾病的发病率分别是白人的四倍和两倍)。英国南亚人面临的健康不平等因他们在健康和基因组研究中的代表性不足而进一步加剧。例如，全球全基因组关联研究(最常见的遗传研究类型之一)的参与者中只有~2%是南亚人，尽管他们占世界人口的25%左右。基因与健康正在成功地纠正这种不平衡，并被证明是全球研究阶段的宝贵贡献者。自2015年启动以来，基因与健康通过与其代表的社区广泛而持久的接触，成功地招募了50,455名志愿者。基因与健康是一种科学资源，可供全球研究界使用，从而确保从这些志愿者的贡献中获得对健康的最大好处。通过基因与健康已经支持的研究，它已经产生了几个主要的影响，包括：i.发现完全的基因敲除如何有助于健康和疾病。支持开发一种治疗一种导致儿童严重健康不良的罕见遗传病的新药(Lumasiran)。这是对一个财团的重大贡献，该财团揭示了我们的基因如何使我们更容易患上COVID-19IV型冠状病毒。利用基因数据改进对谁有患2型糖尿病风险的预测。揭示与儿童成长和青春期有关的新生物途径尽管取得了这些早期的成功，但基因与健康现在正处于关键阶段，其可持续性和增长潜力尚不确定。在MRC纵向人口研究计划的资助下，基因与健康将能够作为对这一人数较少的英国南亚人的健康和疾病的长期研究，与其他有价值的研究队列研究合作，以最大限度地受益。这笔资金还将使基因与健康得到发展，并更好地解决仍未得到满足的健康需求领域，包括精神健康和怀孕健康。我们的建议集中在以下几个方面：1.通过其核心研究团队的支持，支持基因与健康的整体可持续性，超越其现有基础设施资金的持续时间，并生成丰富的纵向数据。提供基因增长和健康“召回”研究，邀请现有志愿者参与其他研究，并具有显著附加值3。扩大心理健康和怀孕方面的数据收集，以解决未得到满足的健康需求领域4。发展基因与健康数据资源，以确保它可以与其他队列研究相结合，以确保分析大于其部分的总和。为此，我们寻求额外的资金，这将支持一些额外的高级学术专家的投入，并扩大个人团队，以实现我们的抱负。

项目成果

CYP2C19 loss-of-function alleles are not associated with higher prevalence of gastrointestinal bleeds in those who have been prescribed antidepressants: Analysis in a British-South Asian cohort

CYP2C19 功能丧失等位基因与服用抗抑郁药的患者胃肠道出血患病率较高无关：英国-南亚队列分析

• DOI: 10.1111/bcp.15762
• 发表时间: 2023
• 期刊: British Journal of Clinical Pharmacology
• 影响因子: 3.4
• 作者: Magavern E