DNP IN CHAR SUSPENSIONS--SURFACE SCIENCE AND OXIMETRY

此FIRCA应用程序的父项目使用电子和核能 磁共振方法研究马兜铃酸的结构和疗效 无机络合物作为临床磁共振顺磁性造影剂的研究 使用。这项拟议中的合作将研究一类新的氧气- 敏感的探测器，最终目标是使用这些炭物种来 动态核极化(DNP)成像、EPR和DNP血氧测定法 申请。总体目标是提高 这些潜在的新造影剂在MRI临床中的应用 (成像和血氧测定。)工作假说是，通过研究 整个类别的焦炭悬浮剂(其中大部分以前曾 合成)在各种实验条件下(高场、低场 现场，可变温度)，他们最终将能够更充分地 理解(并有可能优化)电子-核 多相体系中的极化传递过程。

The parent project for this FIRCA application uses electron and nuclear magnetic resonance methods to study the structure and effectiveness of inorganic complexes as paramagnetic contrast agents for clinical MRI use. This proposed collaboration will study a new class of oxygen- sensitive probes, with the ultimate goal of using these char species for Dynamic Nuclear Polarization (DNP) imaging, EPR and DNP oximetry applications. The overall goal is to increase the effectiveness of these potentially new contrast agents in MRI clinical applications (imaging and oximetry.) The working hypothesis is that by studying the whole class of char suspensions (most of which have previously been synthesized) under a variety of experimental conditions (high field, low field, variable temperature) they will ultimately be able to more fully understand (and possibly be able to optimize) the electron-nuclear polarization transfer process in multiple-phase systems.