RESEARCH TRAINING IN THE NEUROSCIENCES

要求为北卡罗来纳大学教堂山分校神经科学的广泛、全面和基本的跨学科博士前培训计划提供支持。拟议的培训方案旨在合并NIMH和NINDS提供的两项现有培训赠款。培训将由神经生物学的跨部门课程管理，该课程已经存在了第四个十年。培训将涉及该课程的53名教职员工，他们代表14个部门或项目的研究实验室。这些研究设施设备齐全，资金充足，可用于各种解剖学、分子、遗传学、化学、电生理学、行为和生物物理研究。在过去的一年里，该课程与新的北卡罗来纳大学神经科学中心紧密结合，通过发展新的研究实验室和招聘新的教员提供了更多的培训机会。正式的培训计划已经到位，并构成了一系列必修和选修学习活动，从而获得神经生物学博士学位。活动包括最近重组的课程中的正式课程工作，与个别教师导师的实验室学徒研究，重点论文研究，研究研讨会，技术研讨会，临床相关经验，杂志俱乐部和关于职业发展和研究诚信主题的讨论小组。此外，一年一度的卡罗莱纳神经科学研讨会将使受训人员了解北卡罗来纳大学以外杰出科学家提出的专业主题的最新想法。拟议的培训计划将利用北卡罗来纳大学神经生物学研究的几个特殊优势领域，包括：(1)脊髓神经元损伤后的恢复和再生，(2)特定感觉神经功能的分子相关性，(3)神经系统对毒性挑战的反应，(4)神经递质受体和转运体的结构、功能和调节，(5)信号转导和离子通道功能的机制，(6)突触传递和突触发生的细胞和分子生物学，(7)神经内分泌和神经免疫相互作用，(8)神经系统活动的体外、体内和原位功能成像，(9)活跃于中枢神经系统各区域的神经肽的分布和调节。请求为10名博士前实习生提供支持。合格的少数族裔候选人将被积极招募。

Support is requested for a broad, comprehensive and fundamental interdisciplinary predoctoral training program in the neurosciences at the University of North Carolina at Chapel Hill. The proposed training program is intended to consolidate 2 existing training grants from the NIMH and NINDS. The training will be administered by the interdepartmental Curriculum in Neurobiology which is in its fourth decade of existence. Training will involve 53 faculty members of the Curriculum representing research laboratories in 14 departments or programs. These research facilities are well-equipped and funded for a wide variety of anatomical, molecular, genetic, chemical, electrophysiological, behavioral, and biophysical investigations. During the past year the Curriculum has become closely integrated with the new UNC Neuroscience Center providing expanded opportunities for training through the development of new research laboratories and the recruitment of new faculty. The formal training program is already in place and constitutes a series of required and elective learning activities leading to the Ph.D. in Neurobiology. Activities include formal coursework in a recently reorganized curriculum, laboratory apprenticeship research with individual faculty mentors, focused dissertation research, research seminars, techniques seminar, clinical correlation experiences, journal clubs and discussion groups on topics of career development and research integrity. In addition, an annual Carolina Neuroscience Symposium will expose trainees to current thought on specialized topics presented by distinguished scientists from outside UNC. The proposed training program will take advantage of several areas of particular strength in neurobiology research at UNC including: (1) recovery and regeneration following spinal neuron injury, (2) molecular correlations of specific sensory neuronal function, (3) response of the nervous system to toxic challenge, (4) structure, function, and regulation of neurotransmitter receptors and transporters, (5) mechanisms of signal transduction and ion channel function, (6) cell and molecular biology of synaptic transmission and synaptogenesis, (7) neuroendocrine and neuroimmune interactions, (8) functional imaging of nervous system activity in vitro, in vivo, and in situ, and (9) distribution and regulation of neuropeptides active in various regions of the central nervous system. Support is requested for 10 predoctoral trainees. Qualified minority candidates will be aggressively recruited.