RESEARCH TRAINING IN THE NEUROSCIENCES

为北卡罗来纳大学教堂山分校的神经科学领域一个广泛、全面和基础的跨学科博士前培训项目提供支持。拟议的培训计划旨在巩固NIMH和NINDS现有的培训补助金。该培训将由神经生物学跨部门课程管理，该课程已进入第四个十年。培训将涉及代表14个系或项目的研究实验室的53名课程教员。这些研究设施设备齐全，资金充足，可用于各种解剖、分子、遗传、化学、电生理、行为和生物物理研究。在过去的一年中，课程与新的北卡罗来纳大学神经科学中心紧密结合，通过开发新的研究实验室和招聘新的教师，提供了更多的培训机会。正式的培训计划已经到位，并构成了一系列必修和选修的学习活动，从而获得神经生物学博士学位。活动包括最近重组课程的正式课程，与个别教师导师进行的实验室学徒研究，重点论文研究，研究研讨会，技术研讨会，临床相关经验，期刊俱乐部和关于职业发展和研究诚信主题的讨论小组。此外，一年一度的卡罗莱纳神经科学研讨会将使受训者了解由北卡罗来纳大学以外的杰出科学家提出的专业主题的最新思想。拟议的培训计划将利用北卡罗来纳大学神经生物学研究的几个特别优势领域，包括：(1)脊髓神经元损伤后的恢复和再生，(2)特定感觉神经元功能的分子相关性，(3)神经系统对毒性攻击的反应，(4)神经递质受体和转运体的结构、功能和调控，(5)信号转导和离子通道功能机制，(6)突触传递和突触发生的细胞和分子生物学，(7)神经内分泌和神经免疫相互作用，(8)体外、体内和原位神经系统活性的功能成像；(9)中枢神经系统各区域活性神经肽的分布和调控。请支助10名博士预科学员。将积极招募合格的少数族裔候选人。

Support is requested for a broad, comprehensive and fundamental interdisciplinary predoctoral training program in the neurosciences at the University of North Carolina at Chapel Hill. The proposed training program is intended to consolidate 2 existing training grants from the NIMH and NINDS. The training will be administered by the interdepartmental Curriculum in Neurobiology which is in its fourth decade of existence. Training will involve 53 faculty members of the Curriculum representing research laboratories in 14 departments or programs. These research facilities are well-equipped and funded for a wide variety of anatomical, molecular, genetic, chemical, electrophysiological, behavioral, and biophysical investigations. During the past year the Curriculum has become closely integrated with the new UNC Neuroscience Center providing expanded opportunities for training through the development of new research laboratories and the recruitment of new faculty. The formal training program is already in place and constitutes a series of required and elective learning activities leading to the Ph.D. in Neurobiology. Activities include formal coursework in a recently reorganized curriculum, laboratory apprenticeship research with individual faculty mentors, focused dissertation research, research seminars, techniques seminar, clinical correlation experiences, journal clubs and discussion groups on topics of career development and research integrity. In addition, an annual Carolina Neuroscience Symposium will expose trainees to current thought on specialized topics presented by distinguished scientists from outside UNC. The proposed training program will take advantage of several areas of particular strength in neurobiology research at UNC including: (1) recovery and regeneration following spinal neuron injury, (2) molecular correlations of specific sensory neuronal function, (3) response of the nervous system to toxic challenge, (4) structure, function, and regulation of neurotransmitter receptors and transporters, (5) mechanisms of signal transduction and ion channel function, (6) cell and molecular biology of synaptic transmission and synaptogenesis, (7) neuroendocrine and neuroimmune interactions, (8) functional imaging of nervous system activity in vitro, in vivo, and in situ, and (9) distribution and regulation of neuropeptides active in various regions of the central nervous system. Support is requested for 10 predoctoral trainees. Qualified minority candidates will be aggressively recruited.