CORE--CLINICAL

核心--临床

• 批准号: 6345947
• 负责人: J. Dennis Fortenberry
• 金额: $ 13.85万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6345947
• 关键词: adolescence (12-20); biomedical facility; biopsy; blood chemistry; data collection; female; human subject; interview; personal log /diary; questionnaires; sexually transmitted diseases; tissue resource /registry; urinalysis

The purpose of the Clinical Core is to provide biological specimens and behavioral data to all of the individual research projects. This core will be located in Indianapolis. Core research personnel will enroll and maintain the cohort of middle adolescent female research subjects over the five year duration of the center, collect all required biological samples (genitourinary swabs, endocervical secretions, vaginal lavages, urine, cervical biopsies, and blood), behavioral information (self-administered questionnaires and personal interviews), and provide interim reproductive health examinations and data collection to facilitate subject retention. Research personnel will include research coordinator, research nurse practitioner, and two Disease Intervention Specialists (DIS) from the Marion Country Health Department. The research nurse will obtain all biological specimens. DIS will perform two important fieldwork functions: (1) contact sexual partners of subjects to obtained personal information, urine samples, provide appropriate antibiotic treatment when partners of infected women prefer to be treated outside of the Marion County STD Clinic (Bell Flower); (2) weekly contact with all subjects during the three month period of intense data collection to obtain urine samples and self-directed vaginal swabs, personal behavioral diaries and interview information.

临床核心的目的是提供生物标本， 行为数据到所有的个人研究项目。核心将 位于印第安纳波利斯。核心研究人员将入组， 维持中年青春期女性研究对象的队列， 在中心的五年期间，收集所有需要的生物样本 （泌尿生殖器拭子、宫颈内分泌物、阴道灌洗液、尿液， 宫颈活检和血液），行为信息（自我管理 问卷调查和个人访谈），并提供临时生殖 健康检查和数据收集，以促进受试者保留。 研究人员将包括研究协调员、研究护士 医生和两名疾病干预专家（DIS） 马里恩县卫生局。研究护士将获得所有 生物标本DIS将履行两项重要的实地工作职能： (1)接触受试者的性伴侣以获得个人信息， 尿液样本，提供适当的抗生素治疗时，伴侣 受感染的妇女更愿意在马里恩县性病医院以外接受治疗。 诊所（Bell Flower）;（2）在研究期间每周与所有受试者接触 为期三个月的密集数据收集，以获得尿液样本， 自我指导的阴道拭子，个人行为日记和访谈 信息.