STI Developmental Epidemiology of Young Women

这项延续申请建议广泛解决从青春期中后期到青春期的性传播感染的两个一般性问题：1)描述四种性传播生物(沙眼衣原体、淋球菌、阴道毛滴虫和生殖支原体)在青春期和年轻女性及其男性性伴侣中的发育流行病学；2)在12周的密集观察期内，使用每周阴道拭子检查感染获得、持续时间和消退的模式。来自第一个问题的数据可能会为相关的临床和政策问题提供信息，例如STI筛查计划的启动、频率和持续时间。第二个问题的数据还可为预防干预和伴侣治疗等相关问题提供信息。数据将从当前项目的重新注册参与者中收集，年龄在14-21岁之间。季度访问(超过四年)和两次为期3个月的访问 每日日记和每周阴道拭子收集的间隔将与当前项目期间收集的数据合并。新的数据允许关注青春期晚期和青春期早期的性传播感染相关问题。来自两个项目的合并数据(长达75个月的跟踪调查)使人们能够专注于从青春期中期到成年期的整个发展阶段。

This continuation application proposes to extensively address two general questions about STI during the developmental transition from middle and late adolescence into young adulthood: 1) Describe the developmental epidemiology of four sexually transmitted organisms (Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and Mycoplasma genitalium) among adolescent and young adult women and among their male sex partners; 2) examine patterns of infection acquisition, duration and resolution using weekly vaginal swabs over 12-week intensive observation periods. Data from the first question may inform relevant clinical and policy issues such as the initiation, frequency and duration of STI screening programs. Data from the second question could additionally inform issues related to prevention interventions and partner treatment, among others. Data will be collected from re-enrolled participants in current project and are between 14 - 21 years of age. Quarterly visits (over four years) and two 3- month intervals of daily diary and weekly vaginal swab collection will be merged with data collected during the current project period. New data allow focus on STI related issue in late adolescence and early young adulthood. Merged data from both projects (up to 75 months of follow-up) allows focus on a full developmental span from middle adolescence into young adulthood.