STI Developmental Epidemiology of Young Women

本继续申请旨在广泛解决从青春期中后期到成年早期的发育过渡期间有关性传播感染的两个一般性问题：1）描述青少年和年轻成年女性及其男性性伴侣中四种性传播微生物（沙眼衣原体、淋病奈瑟菌、阴道毛滴虫和生殖支原体）的发育流行病学； 2) 在 12 周的密集观察期内，每周使用阴道拭子检查感染的获得模式、持续时间和消退情况。第一个问题的数据可以为相关的临床和政策问题提供信息，例如性传播感染筛查计划的启动、频率和持续时间。第二个问题的数据还可以为与预防干预和伴侣治疗等相关的问题提供信息。数据将从当前项目重新注册的参与者中收集，参与者年龄在 14 至 21 岁之间。每季度访问（四年以上）和两次 3 个月访问 每日日记和每周阴道拭子采集的时间间隔将与当前项目期间收集的数据合并。新数据使人们能够关注青春期晚期和成年早期的性传播感染相关问题。两个项目的合并数据（长达 75 个月的随访）可以重点关注从青春期中期到成年早期的完整发展跨度。

This continuation application proposes to extensively address two general questions about STI during the developmental transition from middle and late adolescence into young adulthood: 1) Describe the developmental epidemiology of four sexually transmitted organisms (Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and Mycoplasma genitalium) among adolescent and young adult women and among their male sex partners; 2) examine patterns of infection acquisition, duration and resolution using weekly vaginal swabs over 12-week intensive observation periods. Data from the first question may inform relevant clinical and policy issues such as the initiation, frequency and duration of STI screening programs. Data from the second question could additionally inform issues related to prevention interventions and partner treatment, among others. Data will be collected from re-enrolled participants in current project and are between 14 - 21 years of age. Quarterly visits (over four years) and two 3- month intervals of daily diary and weekly vaginal swab collection will be merged with data collected during the current project period. New data allow focus on STI related issue in late adolescence and early young adulthood. Merged data from both projects (up to 75 months of follow-up) allows focus on a full developmental span from middle adolescence into young adulthood.