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MECHANISMS OF CEREBRAL MICROVASCULAR CONTROL

脑微血管控制机制

基本信息

批准号：
6125929
负责人：
KEVIN Scott LEE
金额：
$ 17.71万
依托单位：
UNIVERSITY OF VIRGINIA
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
起止时间：
1994-12-01 至 2000-11-30
项目状态：
已结题

项目摘要

DESCRIPTION (Adapted from Applicant's Abstract): Blood flow within the brain is characterized by dynamic spatial and temporal control. The constantly shifting patterns of regional neuronal activity and the high energy demands of active neurons necessitate local mechanisms capable of regulating blood flow in a rapid and precise manner. Parenchymal microvessels are the final cerebrovascular elements responsible for supplying these needs; however, the local mechanisms through which these vessels are regulated are poorly understood. The overall goal of this application is to improve our understanding of how local mechanisms within the brain parenchyma regulate microvascular function under physiological and pathophysiological circumstances. During the initial period of support for this work, we have: 1) developed and tested novel approaches for examining parenchymal microvessels within their normal cellular microenvironment, 2) identified key local mechanisms involved in the regulation of cerebral microvascular tone, and 3) begun to examine how microvascular function is disturbed during metabolic challenge such as occurs after stroke. The Specific Aims of this proposal are to: 1) characterize the roles of local neurons and glia in the regulation of parenchymal microvessels, and 2) elucidate pathophysiological mechanisms contributing to microvascular dysfunction. The proposed studies will provide insights into a fundamental form of intercellular signalling that is involved in coupling local blood flow to local neuronal activity in the brain. A clear understanding of the physiology nd pathophysiology of microvascular control will help identify novel strategies for limiting secondary ischemic injury to the brain.

描述（改编自申请人的摘要）：体内的血流大脑的特点是动态的空间和时间控制。这区域神经元活动模式的不断变化和高活跃神经元的能量需求需要局部机制能够快速而精确地调节血流。实质微血管是最终的脑血管元件，负责满足这些需求；然而，这些地方机制人们对船舶的监管知之甚少。本次活动的总体目标应用程序是为了提高我们对本地机制如何脑实质在生理和心理状态下调节微血管功能病理生理情况。在最初的支持期间在这项工作中，我们：1）开发并测试了新的检查方法正常细胞微环境中的实质微血管，2) 确定了参与脑调节的关键局部机制微血管张力，3) 开始检查微血管功能如何在代谢挑战期间受到干扰，例如中风后发生的情况。这该提案的具体目标是： 1) 描述当地的角色神经元和神经胶质细胞在实质微血管的调节中，2) 阐明微血管的病理生理机制功能障碍。拟议的研究将提供对基本原理的见解参与局部血液耦合的细胞间信号传导形式流向大脑中的局部神经元活动。清楚地了解微血管控制的生理学和病理生理学将有助于识别限制大脑继发性缺血性损伤的新策略。