Securing Transparency And Reproducibility in studies of Nutritional interventions (STAR-Nut)

确保营养干预研究的透明度和可重复性 (STAR-Nut)

• 批准号: MR/Z503824/1
• 负责人: Michael Schlüssel
• 金额: $ 7.6万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FZ503824%2F1
• 关键词: Securing; Transparency; Reproducibility; studies; Nutritional

SummaryMedical research aims to improve people's health. However, it has been suggested that up to 85% of all medical research cannot contribute to our knowledge or be used to improve healthcare practices because it is designed badly, never published, published after a long time, published with insufficient details, or published with only some of the results.The medical research community has investigated these problems over the past decade and funders, journals, and policymakers, among other research users, have proposed and supported initiatives and tools to help researchers conduct and publish their studies well enough so that they can fully contribute to our understanding of health and healthcare.Some of these tools are reporting guidelines. Researchers use these simple checklists when writing a journal article to remember key information they need to include in their manuscripts, so readers can understand the methods used or reproduce the study.There are reporting guidelines for many study designs and clinical areas. Researchers check the quality of papers to assess whether their field is generally good at writing them. If they find that the papers routinely do not mention important information, they might work with experts to create a new reporting guideline. However, they usually do not check whether adequate guidance already exists, or whether the problem is not the lack of guidance but the lack of education or awareness about that guidance.Nutrition science is one area of research that constantly faces controversy. Associations between nutritional factors and health-related outcomes are difficult to measure. A single food can contain several nutrients, and they interact with each other in our body, making it difficult to work out each component's effect. With such complexity, it is vital that nutrition science studies are reported clearly and completely so that their methods can be easily understood and their findings used sensibly - but, unfortunately, the suggestion is that these papers are not well-reported.We are consolidating reporting guidance for studies of nutritional interventions.Today, all trials, including those on nutritional interventions, must be registered before they begin. Based on our background work to map the landscape of nutritional interventions' research and how well it is reported, we will survey nutrition scientists and other users of nutritional interventions' research to discuss whether nutrition science needs its own reporting guidelines. If we find that reporting is poor but a new guideline isn't the answer, we'll also discuss the best way to get existing guidance to researchers and help them to improve the reporting of their studies.Our map of nutritional research today will be useful for researchers and funders, to help them plan and conduct overdue nutritional research. Our final recommendations - for either a new reporting guideline or how to improve the use of existing guidance - will help ensure studies of nutritional interventions are better reported so their methods and results can be more easily understood and used.Reporting research appropriately is an essential component of the research cycle, and therefore an essential component of the research methods. Better papers today will help ensure better-designed studies tomorrow, faster scientific advances in the area of nutritional interventions, and better use of robust scientific evidence for the benefit of patients and the general public.

摘要研究旨在改善人们的健康。但是，有人建议，最多85％的医学研究不能促进我们的知识，也不能用来改善医疗保健实践，因为它的设计良好，从未出版，很长一段时间后出版，并没有足够的详细信息出版，或者仅与一些结果一起出版。进行和发布他们的研究足够好，以便他们可以充分贡献我们对健康和医疗保健的理解。这些工具的某些报告是报告指南。研究人员在撰写期刊文章时使用这些简单的清单来记住他们需要包含在手稿中的关键信息，以便读者可以理解所使用的方法或重现该研究的方法。有关许多研究设计和临床领域的报告指南。研究人员检查论文的质量，以评估其领域是否擅长编写它们。如果他们发现这些论文通常不提及重要信息，他们可能会与专家合作以创建新的报告指南。但是，他们通常不会检查是否已经存在足够的指导，或者问题是否不是缺乏指导，而是缺乏对该指南的教育或意识。营养学是研究领域，不断面临争议。营养因素与与健康相关的结果之间的关联很难衡量。单一食物可以包含几种营养素，它们在我们体内相互作用，因此很难解决每个组件的效果。出于这种复杂性，至关重要的是，营养科学研究的报告清晰，完全完全，以便可以轻松理解其方法，并明智地使用了它们的发现 - 但是，不幸的是，这些论文的建议是，这些论文不是很好地报告。我们正在巩固对营养干预的研究的报告指南。基于我们的背景工作，以绘制营养干预措施的研究的格局及其报道的好处，我们将调查营养科学家和营养干预措施的其他用户的研究，以讨论营养科学是否需要其自己的报告指南。如果我们发现报告很差，但新的指南不是答案，我们还将讨论为研究人员获得现有指导的最佳方法，并帮助他们改善他们的研究报告。我们今天的营养研究地图将对研究人员和资助者有用，以帮助他们计划和进行逾期营养研究。我们的最终建议 - 对于新的报告指南或如何改善现有指南的使用 - 将有助于更好地报告营养干预措施的研究，以便更容易理解和使用其方法和结果。适当地报告研究是研究周期的重要组成部分，因此研究方法是研究方法的重要组成部分。如今，更好的论文将有助于确保明天更好地设计的研究，营养干预领域的更快科学进步，以及更好地利用强大的科学证据，以使患者和公众受益。