IRON STATUS IN WOMEN OF REPRODUCTIVE AGE

育龄女性的铁状况

• 批准号: 6181862
• 负责人: USHA RAMAKRISHNAN
• 金额: $ 10.45万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-15 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6181862
• 关键词: adolescence (12-20); blood chemistry; blood volume; clinical research; dietary iron; disease /disorder proneness /risk; epidemiology; erythrocytes; female; ferritin; hemoglobin; human data; human middle age (35-64); iron disorder; iron metabolism; iron storage disorder; microcytic /hypochromic anemia; nutrition related tag; porphyrins; socioeconomics; transferrin; women's health; young adult human (21-34)

DESCRIPTION: (Adapted from Investigator's Abstract) The overall objective of this application is to characterize current patterns and determinants of iron status in women of reproductive age (12-49 years), using nationally representative data from the recently completed (1988-94) NHANES III. Iron status will be defined in terms of biochemical indicators: serum ferritin, transferrin saturation, erythrocyte porphyrin, mean corpuscular volume and hemoglobin. The Specific Aims include the identification of subgroups at risk for iron deficiency or excess, quantification of trends in iron status over the past 20 years by comparison to results from previous NHANES surveys and assessment of the contributions of supplement use and dietary sources (especially fortified products) to iron intake and status. Dietary data will be based on 24 hour recall and food frequency questionnaires. The sociodemographic correlates of iron deficiency and excess will be identified using multivariate techniques such as logistic regression and general linear models. Sample weights and Strata and Pseudo Primary Sampling Units will be used for calculating variance estimates using the program SUDAAN, which can account for the complex study design of the HANES datasets. Similarly, all the final logistic and ordinary least squares models will also be tested using SUDAAN. The investigators state that this project will help ascertain whether iron deficiency remains a major public health problem in the United States. It will provide an up-to-date picture of iron status among women, including the prevalence of iron excess, which is regarded as an emerging health problem. High iron stores are perceived to increase the risks of hereditary hemochromatosis and chronic disease. Although causality cannot be established due to the limitations of the NHANES, the examination of the strength and direction of the associations of iron excess with predisposing factors for and/or chronic disease is expected to improve significantly current understanding of this emerging area of concern and will be useful for identifying groups at risk and for guiding future research. The investigators state that in summary, the project is expected to provide information that can be used to examine policy options and develop guidelines to ensure adequate but safe iron status for women of reproductive age.

描述：(改编自《调查员摘要》)总体目标 这一应用的目的是表征当前的模式和决定因素 育龄妇女(12-49岁)的铁状况，全国使用 最近完成的(1988-94)NHANES III.铁的代表性数据 状态将根据生化指标来定义：血清铁蛋白， 转铁蛋白饱和度、红细胞卟啉、平均红细胞体积和 血红蛋白。具体目标包括在以下方面确定分组： 铁缺乏或过多的风险，铁状态趋势的量化 与之前的NHANES调查结果相比，过去20年 和评估补充剂的使用和饮食来源的贡献 (特别是强化产品)对铁的摄入量和地位。饮食数据 将基于24小时召回和食物频率调查问卷。这个 将确定铁缺乏和铁过量的社会人口学相关因素 使用Logistic回归和一般线性等多变量技术 模特们。抽样重量、地层和伪主抽样单位 用于使用程序SUDAAN计算方差估计，该程序可以 考虑到HANES数据集的复杂研究设计。同样，所有的 最后的Logistic模型和普通的最小二乘模型也将被测试。 使用SUDAAN。调查人员表示，这个项目将有助于确定 缺铁是否仍然是美国的一个主要公共卫生问题 各州。它将提供女性铁地位的最新图景， 包括铁过剩的流行，这被认为是一个新兴的 健康问题。高铁储存被认为会增加患上 遗传性血色素沉着症和慢性病。尽管因果关系不能 由于NHANES的限制而建立，审查 铁过量与易感的联系的强度和方向 罹患和/或慢性疾病的因素有望显著改善 目前对这一新出现的令人关切的领域的了解，将是有益的 用于识别处于危险中的群体并指导未来的研究。这个 调查人员表示，总而言之，该项目预计将提供 可用于检查政策选项并制定 确保育龄妇女充分但安全的铁地位的指导方针 年龄。