Effect of prenatal DHA supplements on infant development

产前补充 DHA 对婴儿发育的影响

• 批准号: 6772920
• 负责人: USHA RAMAKRISHNAN
• 金额: $ 40.69万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-16 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6772920
• 关键词: child physical development; clinical research; cord blood; cyclic acid; developmental neurobiology; diet therapy; dietary supplements; evoked potentials; gestational age; growth /development; human subject; human therapy evaluation; infant human (0-1 year); nutrition related tag; patient oriented research; pregnancy; prenatal care; socioeconomics; unsaturated fatty acids

DESCRIPTION (provided by applicant): Our research is about the significance of polyunsaturated fatty acids (PUFAs) for human development. Specifically, we will assess the effect of docasohexanoic acid (DHA) supplementation during pregnancy on infant growth and development through a randomized controlled intervention trial in Cuernavaca, Mexico. This will be a collaborative effort among the Department of International Health, Rollins School of Public Health, Emory University, the Instituto Nacional de Salud Publica (INSP) and the Instituto Mexicano del Seguro Social (IMSS), Cuernavaca, Mexico. Pregnant women (n=994) attending the IMSS General Hospital I will be recruited at 20-24 wks gestation and assigned randomly to receive either DHA (200 mg) or a placebo daily until delivery. The main study endpoints include a) birth outcomes: birth size, gestational age, cord blood levels of DHA and neurodevelopment, b) maternal blood and breast milk DHA levels at 1 and 3 mo post-partum), c) postnatal growth and development during the first 18 mo of age and d) infant DHA status at 3, 12 and 18 mo. All data collection will be carried out at the study headquarters (IMSS) except for home environment that will be assessed during home visits at 6 and 12 mo. Physical growth (length, weight, and head circumference) and infant development (Brazelton & Fagan test, visual and auditory evoked potentials, and Bayley scales of infant development) will be measured at birth, 1, 3, 6, 9, 12 and 18 mo by trained nurses and psychologists, respectively. Data will also be obtained on socioeconomic status, obstetric history, maternal diet, anthropometry and intelligence, quality of home environment and infant feeding practices. Data analyses will include group comparisons (intent-to-treat) after ensuring effectiveness of randomization, and structural equation modeling to examine the various pathways by which DHA supplementation during pregnancy affects child growth and development. The findings of this project will contribute significantly to our understanding of the functional consequences of DHA supplementation during pregnancy.

描述（由申请人提供）：我们的研究是关于多不饱和脂肪酸（PUFA）对人类发育的重要性。具体来说，我们将通过在墨西哥库埃纳瓦卡进行的随机对照干预试验来评估怀孕期间补充二十二碳六烯酸 (DHA) 对婴儿生长发育的影响。这将是埃默里大学罗林斯公共卫生学院国际卫生系、国家公共健康研究所 (INSP) 和墨西哥库埃纳瓦卡墨西哥社会保障研究所 (IMSS) 之间的合作成果。 将在妊娠 20-24 周时招募在 IMSS General Hospital I 就诊的孕妇 (n=994)，并随机分配每天接受 DHA（200 毫克）或安慰剂，直至分娩。 主要研究终点包括a) 出生结局：出生大小、胎龄、脐带血DHA 水平和神经发育，b) 产后1 个月和3 个月的母血和母乳DHA 水平)，c) 产后前18 个月的生长和发育，以及d) 3、12 和18 个月的婴儿DHA 状态。所有数据收集都将在研究总部 (IMSS) 进行，家庭环境除外，家庭环境将在第 6 个月和第 12 个月的家访中进行评估。训练有素的护士和心理学家将分别在出生时、出生后 1、3、6、9、12 和 18 个月测量身体生长（身长、体重和头围）和婴儿发育（Brazelton & Fagan 测试、视觉和听觉诱发电位以及婴儿发育贝利量表）。还将获得有关社会经济状况、产科史、母亲饮食、人体测量和智力、家庭环境质量和婴儿喂养方式的数据。数据分析将包括确保随机化有效性后的分组比较（意向治疗）以及结构方程模型，以检查怀孕期间补充 DHA 影响儿童生长和发育的各种途径。该项目的研究结果将极大地有助于我们了解怀孕期间补充 DHA 的功能后果。