Effect of Prenatal DHA Supplements on Infant Development

产前 DHA 补充剂对婴儿发育的影响

• 批准号: 8305032
• 负责人: USHA RAMAKRISHNAN
• 金额: $ 40.45万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-16 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8305032
• 关键词: 5 year old; Acids; Address; Adverse effects; Age; Area; Asthma; Attention; Behavior assessment; Birth; Child; Child Development; Child health care; Cognitive; Cohort Studies; Collaborations; Data; Development; Diet; Dietary intake; Docosahexaenoic Acids; Double-Blind Method; Exposure to; Fishes; Funding; Grant; Growth and Development function; Head circumference; Health; Health Status; Heavy Metals; High birth weight infant; Home environment; Human; Hypersensitivity; Infant Development; Institutes; Life; Light; Link; Live Birth; Measurement; Measures; Memory; Mercury; Mexican; Mexico; Mothers; Motor; N-3 polyunsaturated fatty acid; Parents; Performance; Pesticides; Placebos; Policies; Polyunsaturated Fatty Acids; Population Study; Positioning Attribute; Pregnancy; Pregnant Women; Process; Protocols documentation; Public Health; Randomized; Randomized Controlled Trials; Readiness; Recommendation; Recruitment Activity; Role; Schools; Science; Seafood; Source; Supplementation; Technology; Time; Training; Umbilical Cord Blood; Universities; Update; Visit; Woman; abstracting; cognitive function; cohort; early childhood; executive function; experience; first grade; follow-up; global health; improved; instrument; interest; kindergarten; member; mental development; offspring; prenatal; primary outcome

Abstract This competing renewal builds on successful completion of a double blind randomized controlled trial (RCT) of DHA supplementation during pregnancy in Cuernavaca, Mexico, and is a collaborative effort between the Hubert Department of Global Health, Emory University in Atlanta GA and the National Institute of Public Health (INSP) in Cuernavaca, Mexico. The overall objective is to extend to age 5 y our examination of the effects on the offspring of maternal supplementation during pregnancy with docosahexaenoic acid (DHA). Our central hypothesis is that DHA supplementation during pregnancy will improve early childhood development. In the original trial, 1094 pregnant women were randomized to receive daily a supplement of 400 mg of DHA or a placebo from 18-22 weeks of pregnancy. The 973 live births are currently being followed up to age 18 mos for measures of growth and development. We propose to study the birth cohort at age 5 y. We plan to collect a comprehensive set of measures of early childhood development (ECD) that are known to predict later intellectual functioning. The primary outcomes include global motor and mental development, executive functioning, specifically attention and memory, and inhibitory processes. Additional data on dietary intakes, health and exposure to early childhood stimulation both at the home and outside will also be obtained. All measurements will be obtained by a well trained and experienced field team; many team members participated in the parent study and have developed good rapport with the study population. We expect to recruit at least 85% of the eligible birth cohort and will have adequate power to detect effect sizes of 0.3 S.D. We will link these new data to our extraordinarily rich array of data that we collected prenatally, at birth, and at ages 1, 3, 6, 9, 12 and 18 mos. In addition to analyses that focus on the overall impact of supplementation with DHA, we will explore hypotheses concerning developmental trajectories. These data will also position us to continue to follow this cohort during their early school years.

摘要

项目成果

Auditory- and visual-evoked potentials in Mexican infants are not affected by maternal supplementation with 400 mg/d docosahexaenoic acid in the second half of pregnancy.

墨西哥婴儿的听觉和视觉诱发电位不受母亲在妊娠后半期补充 400 毫克/天二十二碳六烯酸的影响。

• DOI: 10.3945/jn.112.162461
• 发表时间: 2012
• 期刊: The Journal of nutrition
• 作者: Stein,AryehD;Wang,Meng;Rivera,JuanA;Martorell,Reynaldo;Ramakrishnan,Usha
• 通讯作者: Ramakrishnan,Usha

Breastfeeding status at age 3 months is associated with adiposity and cardiometabolic markers at age 4 years in Mexican children.

• DOI: 10.3945/jn.114.198366
• 发表时间: 2015-06
• 期刊: The Journal of nutrition
• 作者: I. Ramírez-Silva;J. Rivera;B. Trejo-Valdivia;R. Martorell;A. Stein;I. Romieu;A. Barraza‐Villarreal;U. Ramakrishnan

Growth to age 18 months following prenatal supplementation with docosahexaenoic acid differs by maternal gravidity in Mexico.

在墨西哥，产前补充二十二碳六烯酸后生长至 18 个月的年龄因母亲妊娠情况而异。

• DOI: 10.3945/jn.110.128215
• 发表时间: 2011
• 期刊: The Journal of nutrition
• 作者: Stein,AryehD;Wang,Meng;Martorell,Reynaldo;Neufeld,LynnetteM;Flores-Ayala,Rafael;Rivera,JuanA;Ramakrishnan,Usha
• 通讯作者: Ramakrishnan,Usha

Reply to GC Burdge.

回复 GC 伯奇。

• DOI: 10.3945/ajcn.113.072272
• 发表时间: 2013
• 期刊: The American journal of clinical nutrition
• 作者: Lee,Ho-Sun;Hernandez-Vargas,Hector;Biessy,Carine;Romieu,Isabelle;Herceg,Zdenko;Barraza-Villarreal,Albino;Sly,PeterD;Ramakrishnan,Usha
• 通讯作者: Ramakrishnan,Usha

Prenatal exposure to environmental pollutants and child development trajectories through 7 years.

• DOI: 10.1016/j.ijheh.2018.04.004
• 发表时间: 2018-05
• 期刊: International journal of hygiene and environmental health
• 影响因子: 6
• 作者: Gonzalez-Casanova I;Stein AD;Barraza-Villarreal A;Feregrino RG;DiGirolamo A;Hernandez-Cadena L;Rivera JA;Romieu I;Ramakrishnan U
• 通讯作者: Ramakrishnan U