IRON STATUS IN WOMEN OF REPRODUCTIVE AGE

育龄女性的铁状况

• 批准号: 2889307
• 负责人: USHA RAMAKRISHNAN
• 金额: $ 10.66万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-15 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2889307
• 关键词: adolescence (12-20); blood chemistry; blood volume; clinical research; dietary iron; disease /disorder proneness /risk; epidemiology; erythrocytes; female; ferritin; hemoglobin; human data; human middle age (35-64); iron disorder; iron metabolism; iron storage disorder; microcytic /hypochromic anemia; nutrition related tag; porphyrins; socioeconomics; transferrin; women's health; young adult human (21-34)

DESCRIPTION: (Adapted from Investigator's Abstract) The overall objective of this application is to characterize current patterns and determinants of iron status in women of reproductive age (12-49 years), using nationally representative data from the recently completed (1988-94) NHANES III. Iron status will be defined in terms of biochemical indicators: serum ferritin, transferrin saturation, erythrocyte porphyrin, mean corpuscular volume and hemoglobin. The Specific Aims include the identification of subgroups at risk for iron deficiency or excess, quantification of trends in iron status over the past 20 years by comparison to results from previous NHANES surveys and assessment of the contributions of supplement use and dietary sources (especially fortified products) to iron intake and status. Dietary data will be based on 24 hour recall and food frequency questionnaires. The sociodemographic correlates of iron deficiency and excess will be identified using multivariate techniques such as logistic regression and general linear models. Sample weights and Strata and Pseudo Primary Sampling Units will be used for calculating variance estimates using the program SUDAAN, which can account for the complex study design of the HANES datasets. Similarly, all the final logistic and ordinary least squares models will also be tested using SUDAAN. The investigators state that this project will help ascertain whether iron deficiency remains a major public health problem in the United States. It will provide an up-to-date picture of iron status among women, including the prevalence of iron excess, which is regarded as an emerging health problem. High iron stores are perceived to increase the risks of hereditary hemochromatosis and chronic disease. Although causality cannot be established due to the limitations of the NHANES, the examination of the strength and direction of the associations of iron excess with predisposing factors for and/or chronic disease is expected to improve significantly current understanding of this emerging area of concern and will be useful for identifying groups at risk and for guiding future research. The investigators state that in summary, the project is expected to provide information that can be used to examine policy options and develop guidelines to ensure adequate but safe iron status for women of reproductive age.

描述：（改编自研究者摘要）总体目的 本申请的主要目的是表征 全国育龄妇女（12-49岁）铁营养状况 最近完成的（1988-94）NHANES III的代表性数据。 铁 根据生化指标定义状态：血清铁蛋白， 转铁蛋白饱和度，红细胞卟啉，平均红细胞体积和 血红蛋白。 具体目标包括确定 铁缺乏或过量的风险，铁状态趋势的量化 与以往NHANES调查结果相比， 补充剂的使用和膳食来源的贡献的评估 （特别是强化产品）铁摄入量和状态。 饮食数据 将基于24小时回忆和食物频率问卷。 的 将确定铁缺乏和过量的社会人口学相关性 使用多变量技术，例如逻辑回归和一般线性回归， 模型 样本重量、分层和伪主要采样单位将 用于使用程序SUDAAN计算方差估计值，该程序可以 解释了HANES数据集的复杂研究设计。 同样地，所有 最后的逻辑模型和普通最小二乘模型也将被检验 使用SUDAAN。 调查人员表示，该项目将有助于确定 铁缺乏是否仍然是美国的一个主要公共卫生问题 States. 它将提供妇女体内铁含量状况的最新情况， 包括普遍存在的铁过剩，这被认为是一个新兴的 健康问题。 高铁储存被认为会增加 遗传性血色病和慢性病。 虽然因果关系不能 由于NHANES的局限性， 铁过剩与易感性的关联的强度和方向 和/或慢性疾病的因素，预计将显着改善 目前对这一新出现的关切领域的理解， 用于识别风险群体和指导未来的研究。 的 调查人员说，总的来说，该项目预计将提供 可用于审查政策选择和制定 确保育龄妇女获得充足但安全的铁营养的指导方针 年龄