DELIVERY OF ANTIGENS TO THE MHC CLASS I PROCESSING PATHWAY

将抗原递送至 MHC I 类加工途径

• 批准号: 6160682
• 负责人: J W YEWDELL
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6160682
• 关键词: MHC class I antigen; Orthomyxoviridae; T cell receptor; antigen presentation; antigenic peptide transporter; cytoplasm; cytotoxic T lymphocyte; endopeptidases; endoplasmic reticulum; intracellular transport; laboratory mouse; recombinant virus; tissue /cell culture; vaccinia virus; virus antigen; virus protein

CD8 positive lymphocytes (T/CD8+) play an important role in host immunity to viruses . Anti-viral T/CD8+ recognize MHC class I molecules bound to peptides derived from a cytosolic pool of viral proteins. One of the curious features of T/CD8+ responses to viral infections is that it typically focuses on a highly limited set of peptides. This phenomenon, termed immunodominance, is crucial to understand if we are to develop vaccines that optimally elicit T/CD8+ responses. In this project we are investigating the various factors that contribute to immunodominance, including antigen processing, T cell regulation, and T cell receptor repertoire.

CD8+淋巴细胞(T/CD8+)在宿主中发挥重要作用 对病毒免疫。抗病毒T/CD8+识别MHC I类分子 与来自病毒蛋白胞质池的多肽结合。一 T/CD8+对病毒感染的反应的奇怪特征之一是 它通常专注于一组高度有限的多肽。这 这种现象被称为免疫优势，对于理解我们是不是 开发以最佳方式激发T/CD8+反应的疫苗。在这 我们正在调查各种因素对 免疫优势，包括抗原处理，T细胞调节，以及 T细胞受体谱系。