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DELIVERY OF ANTIGENS TO THE MHC CLASS I PROCESSING PATHWAY

DELIVERY OF ANTIGENS TO THE MHC CLASS I PROCESSING PATHWAY
将抗原递送至 MHC I 类加工途径
批准号：
6160682
负责人：
J W YEWDELL
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6160682
关键词：
MHC class I antigen Orthomyxoviridae T cell receptor antigen presentation antigenic peptide transporter cytoplasm cytotoxic T lymphocyte endopeptidases endoplasmic reticulum intracellular transport laboratory mouse recombinant virus tissue /cell culture vaccinia virus virus antigen virus protein

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英文摘要
CD8 positive lymphocytes (T/CD8+) play an important role in host immunity to viruses . Anti-viral T/CD8+ recognize MHC class I molecules bound to peptides derived from a cytosolic pool of viral proteins. One of the curious features of T/CD8+ responses to viral infections is that it typically focuses on a highly limited set of peptides. This phenomenon, termed immunodominance, is crucial to understand if we are to develop vaccines that optimally elicit T/CD8+ responses. In this project we are investigating the various factors that contribute to immunodominance, including antigen processing, T cell regulation, and T cell receptor repertoire.
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ANTIGEN PROCESSING IN LOWER EUKARYOTIC CELLS
ASSEMBLY, INTRACELLULAR TRAFFICKING, AND FUNCTION OF MHC CLASS IB
PROCESSING OF VIRAL PROTEINS FOR T CELL RECOGNITION
FOLDING, ASSEMBLY, AND TRANSPORT OF VIRAL GLYCOPROTEINS