ASSEMBLY, INTRACELLULAR TRAFFICKING, AND FUNCTION OF MHC CLASS IB

IB 类 MHC 的组装、细胞内运输和功能

• 批准号: 6160731
• 负责人: J W YEWDELL
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6160731
• 关键词: CD antigens; MHC class I antigen; antigen presentation; antigenic peptide transporter; cytotoxic T lymphocyte; intracellular transport; laboratory mouse; protein structure function; recombinant virus; tissue /cell culture; vaccinia virus; virus antigen

Classical class I molecules present endogenous peptide antigens for recognition by cytotoxic T lymphocytes. Nonclassical class I (class Ib) molecules, although similar in structure to classical class I molecules, have an unknown function. In this project we are studying the cell biology biochemistry, and function of two representative mouse class Ib molecules, Q7b and mCD1.1, with the ultimate goal of determining the role of these molecules in anti-viral immune responses.

经典的I类分子呈递内源性肽抗原， 通过细胞毒性T淋巴细胞识别。 非经典I类（Ib类） 分子，尽管结构与经典的I类分子相似， 有一个未知的功能。 在这个项目中，我们正在研究细胞 生物学、生物化学和功能 分子，Q7b和mCD1.1，最终目标是确定 这些分子在抗病毒免疫应答中的作用。