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ASSEMBLY, INTRACELLULAR TRAFFICKING, AND FUNCTION OF MHC CLASS IB

ASSEMBLY, INTRACELLULAR TRAFFICKING, AND FUNCTION OF MHC CLASS IB
IB 类 MHC 的组装、细胞内运输和功能
批准号：
6160731
负责人：
J W YEWDELL
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6160731
关键词：
CD antigens MHC class I antigen antigen presentation antigenic peptide transporter cytotoxic T lymphocyte intracellular transport laboratory mouse protein structure function recombinant virus tissue /cell culture vaccinia virus virus antigen

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英文摘要
Classical class I molecules present endogenous peptide antigens for recognition by cytotoxic T lymphocytes. Nonclassical class I (class Ib) molecules, although similar in structure to classical class I molecules, have an unknown function. In this project we are studying the cell biology biochemistry, and function of two representative mouse class Ib molecules, Q7b and mCD1.1, with the ultimate goal of determining the role of these molecules in anti-viral immune responses.
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ANTIGEN PROCESSING IN LOWER EUKARYOTIC CELLS
ASSEMBLY, INTRACELLULAR TRAFFICKING, AND FUNCTION OF MHC CLASS IB
PROCESSING OF VIRAL PROTEINS FOR T CELL RECOGNITION
FOLDING, ASSEMBLY, AND TRANSPORT OF VIRAL GLYCOPROTEINS
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