ASSESSMENT OF LYMPHOCYTES IN AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME

自身免疫性淋巴细胞增殖综合征中淋巴细胞的评估

• 批准号: 6161568
• 负责人: T A FLEISHER
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6161568
• 关键词: B lymphocyte; T lymphocyte; autoimmune disorder; clinical research; genetic disorder; human subject; immunopathology diagnosis; lymphocyte proliferation; surface antigens

An extensive evaluation has been undertaken of patients with auto-immune lympho-proliferative syndrome (ALPS) and their extended-family members, based on characterization of the expanded double negative T-cell and B- cell populations. To date the double negative T-cells have been demonstrated to be alpha beta TcR, CD57+, HLA-DR+, and CD45RA+. In addition, a number of asymptomatic family members appear to have an increased level of double negative T-cells.

一项广泛的评估已经进行了患者的自身免疫性 淋巴增生综合征（ALPS）及其家族成员， 基于扩增的双阴性T细胞和B-细胞的表征， 细胞群到目前为止，双阴性T细胞已经被 证实为α β TcR、CD 57+、HLA-DR+和CD 45 RA+。在 此外，一些无症状的家庭成员似乎患有 双阴性T细胞水平升高。