STATISTICAL ANALYSIS OF MOLECULAR GENETICS OF CARDIOVASCULAR DISEASE

心血管疾病分子遗传学统计分析

• 批准号: 6162612
• 负责人: A F WILSON
• 金额: --
• 依托单位: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6162612
• 关键词: African American; atrial natriuretic peptide; blood pressure; cardiovascular disorder; clinical research; gene expression; genetic markers; genotype; human subject; linkage mapping; molecular genetics; peptidyl dipeptidase A; renin angiotensin system; sodium potassium exchanging ATPase; statistics /biometry

The purpose of the project is to identify genes involved in cardiovascular disorders using genetic markers and statistical genetic analyses. The markers studied include probes for candidate genes for angiotension converting enzyme, Na-K-ATPase, renin and atrial natriuretic factor, as well as anonymous DNA markers. Using genotyping data from the University of Cincinnati, model-independent sib pair linkage analysis was used to identify possible regions involved in the variation of blood pressure measures. The sample includes over 100 sib pairs, primarily African-Americans.

该项目的目的是识别与 利用遗传标记和统计遗传学研究心血管疾病 分析。所研究的标记包括对候选基因的探针 血管紧张素转换酶、Na-K-ATPase、肾素和心钠素 因素，以及匿名DNA标记。使用来自 辛辛那提大学，模型独立的同胞对连锁分析 用于识别血液变化中可能涉及的区域 压力测量。样本包括100多对同胞，主要是 非裔美国人。