STATISTICL PROPERTIES OF VARIANCE COMPONENTS AND SIB PAIR LINKAGE ANALYSIS

同胞对和方差分量关联的统计性质 方法使用来自问题2的核心家庭数据进行比较 基因分析研讨会10.总体而言，检测连锁的能力是 无论是哪种方法，都不算高。方差分量法最好 检测连锁的能力，特别是当协变量 包括在模型中。第I类错误率与标称误差相似 这两种方法的费率。

The statistical properties of sib-pair and variance-components linkage methods were compared using the nuclear family data from problem 2 of the Genetic Analysis Workshop 10. Overall, the power to detect linkage was not high for either method. The variance-components method had better power for the detection of linkage, particularly when covariates were included in the model. Type I error rates were similar to nominal error rates for both methods.