STATISTICL PROPERTIES OF VARIANCE COMPONENTS AND SIB PAIR LINKAGE ANALYSIS

方差分量的统计特性和同胞对连锁分析

• 批准号: 6162620
• 负责人: A F WILSON
• 金额: --
• 依托单位: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6162620
• 关键词: analytical method; evaluation /testing; linkage mapping; performance; problem solving; statistics /biometry

The statistical properties of sib-pair and variance-components linkage methods were compared using the nuclear family data from problem 2 of the Genetic Analysis Workshop 10. Overall, the power to detect linkage was not high for either method. The variance-components method had better power for the detection of linkage, particularly when covariates were included in the model. Type I error rates were similar to nominal error rates for both methods.

同胞对与方差分量连锁的统计性质 方法进行了比较，使用核心家庭的数据，从问题2的 10.第10章.总体而言，检测关联的功效为 这两种方法都不高。方差分量法较好 检测关联的把握度，特别是当协变量 包括在该模型中。I类错误率与标称错误率相似 这两种方法的价格。