STATISTICAL GENETIC ANALYSIS OF HYPERTENSIVE PHENOTYPES--FAMILY STUDIES

老年人高血压相关特征的家庭资料 奥康纳博士和帕默博士收集了300个个体 在加州大学圣迭戈分校。该项目的目标是调查这种变化 在与交感神经效应器连接相关的特征中 并最终导致血压和高血压的变化，以及 试图确定遗传成分是否 对这种变化负有责任，至少是部分责任。计算机模拟 已经进行了研究，以确定样本对 检测链接。该项目的基因分型已获得世界卫生组织批准 遗传病研究中心访问委员会。这个 其他表型信息的收集是有条件的 获得额外的NIH资金。

Family data on traits related to hypertension on over 300 individuals have been collected by Drs. O'Connor and Parmer at UCSD. The objective of the project is to investigate the variation in traits related to aspects of the sympatheic neuroeffector juction and ultimately in changes in blood pressure and hypertension, and to attempt to determine whether genetic components are responsible, at least in part, for this variation. Computer simulation studies have been done to determine the power of the sample to detect linkage. Genotyping for the project has been approved by the Center for Inherited Disease Research Access Committee. The collection of additional phenotyping information is conditional on obtaining additional NIH funding.