STATISTICAL GENETIC ANALYSIS OF HYPERTENSIVE PHENOTYPES--FAMILY STUDIES

高血压表型的统计遗传学分析--家族研究

• 批准号: 6109034
• 负责人: A F WILSON
• 金额: --
• 依托单位: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6109034
• 关键词: blood pressure; clinical research; computer simulation; familial hypertension; family genetics; gene expression; genetic polymorphism; genotype; human subject; hypertension; linkage mapping; neuroeffector; phenotype; statistics /biometry

Family data on traits related to hypertension on over 300 individuals have been collected by Drs. O'Connor and Parmer at UCSD. The objective of the project is to investigate the variation in traits related to aspects of the sympatheic neuroeffector juction and ultimately in changes in blood pressure and hypertension, and to attempt to determine whether genetic components are responsible, at least in part, for this variation. Computer simulation studies have been done to determine the power of the sample to detect linkage. Genotyping for the project has been approved by the Center for Inherited Disease Research Access Committee. The collection of additional phenotyping information is conditional on obtaining additional NIH funding.

2000年以上高血压相关性状的家系资料 奥康纳博士和帕默博士收集了300个个体 在UCSD该项目的目的是调查变化 与交感神经效应器相关的特征 最终导致血压和高血压的变化， 试图确定基因成分是否 至少部分原因是因为这种变化。计算机模拟 已经进行了研究，以确定样本的功效， 检测链接。该项目的基因分型已获得 遗传疾病研究中心访问委员会。的 收集额外的表型信息的条件是 获得更多的NIH资金。