IDENTIFICATION OF GENES FOR HYPERTENSION/SALT SENSITIVITY IN AFRICAN AMERICANS
非洲裔美国人高血压/盐敏感性基因的鉴定
基本信息
- 批准号:6162613
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Previous collaborations with Dr. Svetkey suggested evidence for linkage
between a marker on chromosome 5, at or near the beta-2-adrenergic
receptor, that was responsible, at least in part, for the phenotypic
variation of diastolic blood pressure after salt loading and depletion.
Additional genotyping of markers flanking the putative locus failed to
show evidence of linkage, although the previous finding was corroborated
using the variance-components method of linkage analysis. The estimated
recombination fractions between the flanking markers were considerably
larger in this population of predominantly female African-Americans than
reported in other populations. Estimates of heritability suggest that at
least some of the traits related to salt- sensitivity are high,
suggesting that genetic components may play a substantial role in the
expression of blood pressure after exposure to salt loading.
之前与Svetkey博士的合作提出了关联的证据
项目成果
期刊论文数量(0)
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会议论文数量(0)
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A F WILSON其他文献
A F WILSON的其他文献
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{{ truncateString('A F WILSON', 18)}}的其他基金
STATISTICL PROPERTIES OF VARIANCE COMPONENTS AND SIB PAIR LINKAGE ANALYSIS
方差分量的统计特性和同胞对连锁分析
- 批准号:
6162620 - 财政年份:
- 资助金额:
-- - 项目类别:
STATISTICAL ANALYSIS OF MOLECULAR GENETICS OF CARDIOVASCULAR DISEASE
心血管疾病分子遗传学统计分析
- 批准号:
6162612 - 财政年份:
- 资助金额:
-- - 项目类别:
STATISTICAL GENETIC ANALYSIS OF HYPERTENSIVE PHENOTYPES--FAMILY STUDIES
高血压表型的统计遗传学分析--家族研究
- 批准号:
6162615 - 财政年份:
- 资助金额:
-- - 项目类别:
GASP--A SOFTWARE TOOL FOR METHODOLOGIC DEVELOPMENT IN STATISTICAL GENETICS
GASP——统计遗传学方法开发的软件工具
- 批准号:
6162617 - 财政年份:
- 资助金额:
-- - 项目类别:
STATISTICAL GENETIC ANALYSIS OF HYPERTENSIVE PHENOTYPES--FAMILY STUDIES
高血压表型的统计遗传学分析--家族研究
- 批准号:
6109034 - 财政年份:
- 资助金额:
-- - 项目类别: