IDENTIFICATION OF GENES FOR HYPERTENSION/SALT SENSITIVITY IN AFRICAN AMERICANS

非洲裔美国人高血压/盐敏感性基因的鉴定

基本信息

项目摘要

Previous collaborations with Dr. Svetkey suggested evidence for linkage between a marker on chromosome 5, at or near the beta-2-adrenergic receptor, that was responsible, at least in part, for the phenotypic variation of diastolic blood pressure after salt loading and depletion. Additional genotyping of markers flanking the putative locus failed to show evidence of linkage, although the previous finding was corroborated using the variance-components method of linkage analysis. The estimated recombination fractions between the flanking markers were considerably larger in this population of predominantly female African-Americans than reported in other populations. Estimates of heritability suggest that at least some of the traits related to salt- sensitivity are high, suggesting that genetic components may play a substantial role in the expression of blood pressure after exposure to salt loading.
之前与Svetkey博士的合作提出了关联的证据

项目成果

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A F WILSON其他文献

A F WILSON的其他文献

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{{ truncateString('A F WILSON', 18)}}的其他基金

STATISTICL PROPERTIES OF VARIANCE COMPONENTS AND SIB PAIR LINKAGE ANALYSIS
方差分量的统计特性和同胞对连锁分析
  • 批准号:
    6162620
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    --
  • 项目类别:
GENETICS OF OBESITY IN THE AMISH
阿米什人肥胖的遗传学
  • 批准号:
    6162610
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  • 资助金额:
    --
  • 项目类别:
STATISTICAL ANALYSIS OF MOLECULAR GENETICS OF CARDIOVASCULAR DISEASE
心血管疾病分子遗传学统计分析
  • 批准号:
    6162612
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  • 资助金额:
    --
  • 项目类别:
STATISTICAL GENETIC ANALYSIS OF HYPERTENSIVE PHENOTYPES--FAMILY STUDIES
高血压表型的统计遗传学分析--家族研究
  • 批准号:
    6162615
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    --
  • 项目类别:
GASP--A SOFTWARE TOOL FOR METHODOLOGIC DEVELOPMENT IN STATISTICAL GENETICS
GASP——统计遗传学方法开发的软件工具
  • 批准号:
    6162617
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  • 资助金额:
    --
  • 项目类别:
STATISTICAL GENETIC ANALYSIS OF HYPERTENSIVE PHENOTYPES--FAMILY STUDIES
高血压表型的统计遗传学分析--家族研究
  • 批准号:
    6109034
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    --
  • 项目类别:
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