非洲裔美国人高血压/盐敏感性基因的鉴定-猫眼课题宝

非洲裔美国人高血压/盐敏感性基因的鉴定

批准号：

6162613

负责人：

A F WILSON

金额：

$0.0万

依托单位：

NATIONAL HUMAN GENOME RESEARCH INSTITUTE

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/6162613

关键词：

African American angiotensin /renin /aldosterone hypertension beta adrenergic receptor blood pressure clinical research familial hypertension gene expression genetic markers genotype human subject linkage mapping phenotype

中文摘要

翻译

之前与Svetkey博士的合作提出了关联的证据

英文摘要

Previous collaborations with Dr. Svetkey suggested evidence for linkage between a marker on chromosome 5, at or near the beta-2-adrenergic receptor, that was responsible, at least in part, for the phenotypic variation of diastolic blood pressure after salt loading and depletion. Additional genotyping of markers flanking the putative locus failed to show evidence of linkage, although the previous finding was corroborated using the variance-components method of linkage analysis. The estimated recombination fractions between the flanking markers were considerably larger in this population of predominantly female African-Americans than reported in other populations. Estimates of heritability suggest that at least some of the traits related to salt- sensitivity are high, suggesting that genetic components may play a substantial role in the expression of blood pressure after exposure to salt loading.

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