LARGE-SCALE PRODUCTION & PURIFICATION OF COMPOUNDS WITH BIOLOGICAL ACTIVITY

大规模生产

基本信息

项目摘要

The Biotechnology Unit is responsible for the production and purification of biological material. The Unit undertakes a wide array of biological production tasks such as large-scale growth of prokaryotic cells and eucaryotic cells, production of various compounds from microorganixms and eucaryotic cells, and purification of biological compounds especially proteins. These products, not available from commercial sources, are needed for clinical and structural studies. The Biotechnology Unit is capable of handling various production problems associated with widely different topics by implementing both physiological and technical approaches. Efficient process development and production is possible since the Unit possesses two integrated elements: a fully operational multi-purpose pilot production facility and the capability of conducting research and process development. During the last year the unit performed approximately 200 different, large scale preparations: 1) Growing various microorganisms such as recombinant Escherichia coli, recombinant Saccharomyces cerevisiae, recombinant Pichia pastoria, mutant strains of Bortedella pertussis, mutant strains of Corynebacteria diphtheria and several types of Salmonella and Shigella. 2) Propagating large volumes of various mammalian cells, and 3) purifying gram quantities of diphtheria toxin CRM (Cross Reacting Material) and recombinant pseudomonas aeruginosa exotoxin A. In the research and development area the unit continues: 1) its effort on the development of more efficient methods for large scale protein recovery, performing experiments implementing expanded bed absorption techniques for capturing proteins on an ion exchangers and chelating resins; 2) conducting research work aimed at understanding the glucose metabolism of various recombinant E. coli strains, in an effort to determine why certain strains are more suitable for foreign protein production; and 3) exploring methods for propagation of anchorage dependent mammalian cells, such as cell cubes and fluidized bed.
生物技术股负责生产和

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

J SHILOACH其他文献

J SHILOACH的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('J SHILOACH', 18)}}的其他基金

LARGE-SCALE PROCESSING OF BIOLOGICAL MATERIALS
生物材料的大规模加工
  • 批准号:
    3896978
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
LARGE-SCALE PROCESSING OF BIOLOGICAL MATERIALS
生物材料的大规模加工
  • 批准号:
    3875545
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
LARGE-SCALE PRODUCTION & PURIFICATION OF COMPOUNDS WITH BIOLOGICAL ACTIVITY
大规模生产
  • 批准号:
    3839587
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
LARGE-SCALE PRODUCTION & PURIFICATION OF COMPOUNDS WITH BIOLOGICAL ACTIVITY
大规模生产
  • 批准号:
    5201906
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
LARGE-SCALE PROCESSING OF BIOLOGICAL MATERIAL
生物材料的大规模加工
  • 批准号:
    3854538
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
LARGE-SCALE PROCESSING OF BIOLOGICAL MATERIALS
生物材料的大规模加工
  • 批准号:
    3964020
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
LARGE-SCALE PROCESSING OF BIOLOGICAL MATERIALS
生物材料的大规模加工
  • 批准号:
    4689026
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
LARGE-SCALE PRODUCTION & PURIFICATION OF COMPOUNDS WITH BIOLOGICAL ACTIVITY
大规模生产
  • 批准号:
    2572772
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
LARGE-SCALE PROCESSING OF BIOLOGICAL MATERIALS
生物材料的大规模加工
  • 批准号:
    3917366
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:

相似海外基金

Pioneering reproductive biotechnology innovations for equine breeding
开创马匹育种生殖生物技术创新
  • 批准号:
    LP230100156
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Linkage Projects
Industrial Biotechnology Innovation Cluster
产业生物技术创新集群
  • 批准号:
    EP/Y024168/1
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Research Grant
Environmental Biotechnology Innovation Centre
环境生物技术创新中心
  • 批准号:
    BB/Y008332/1
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Research Grant
Shear Innovation: Valorising wool waste using biotechnology to enhance horticultural peat-free growing media
剪切创新:利用生物技术提高羊毛废料的价值,以增强园艺无泥炭生长介质
  • 批准号:
    10106787
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Launchpad
Conference: Translating Molecular Science Innovations into Biotechnology Solutions
会议:将分子科学创新转化为生物技术解决方案
  • 批准号:
    2419731
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
MFB: Partnerships to Transform Emerging Industries - RNA Tools/Biotechnology: Stabilizing Hairpin Inserts in RNA Virus Induced Gene Silencing Vectors
MFB:合作变革新兴产业 - RNA 工具/生物技术:稳定 RNA 病毒诱导基因沉默载体中的发夹插入
  • 批准号:
    2330663
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
I-Corps: Translation potential of a miniaturized biotechnology platform for nucleic acid extraction, purification, and library preparation
I-Corps:用于核酸提取、纯化和文库制备的小型生物技术平台的转化潜力
  • 批准号:
    2421022
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
NSF Convergence Accelerator Track M: Biofilm-based Corrosion Control using 3D Printed Biotechnology
NSF 融合加速器轨道 M:使用 3D 打印生物技术进行基于生物膜的腐蚀控制
  • 批准号:
    2344389
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Engineering Biology Hub for environmental processing and recovery of metals; from contaminated land to industrial biotechnology in a circular economy
用于环境处理和金属回收的工程生物中心;
  • 批准号:
    BB/Y008456/1
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Research Grant
Development of magnetic force biotechnology to facilitate neural regeneration
开发磁力生物技术促进神经再生
  • 批准号:
    EP/X014126/1
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了